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Senescent and apoptotic osteocytes and aging: Exercise to the rescue?

07:00 EST 5th February 2019 | BioPortfolio

Summary of "Senescent and apoptotic osteocytes and aging: Exercise to the rescue?"

Osteocytes are the most prevalent cell in the skeleton and are the master regulator of bone remodeling. Despite the understanding that osteocytes have a multiyear lifespan, and some factors induce apoptosis in osteocytes, much less is understood about the induction and consequences of osteocyte senescence. Filling these gaps in knowledge will provide novel approaches to slowing age-related bone loss and preventing fragility fractures. The purpose of this review is to examine the roles of senescence and apoptosis in osteocytes in age-related bone loss. Based on evidence that exercise can prevent senescence in skeletal muscle, we provide a novel hypothesis by which exercise can prolong skeletal health.

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This article was published in the following journal.

Name: Bone
ISSN: 1873-2763
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Medical and Biotech [MESH] Definitions

Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi.

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