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Analysis of affinity-purified PSD-95 complexes had previously identified a 'hypothetical protein', product of the gene FAM81 A . The present study examined the tissue and subcellular distribution of FAM81 A protein and its expression levels during development. Comparison of different organs indicates selective expression of FAM81 A protein in brain. FAM81 A is expressed late in development, with a post-natal gradual increase in brain levels that parallels the expression of PSD-95. Comparison of subcellular fractions from adult brain shows that the distribution of FAM81 A protein is similar to that of PSD-95, with a drastic enrichment in the postsynaptic density fraction. Immuno-electron microscopy of adult brain tissue reveals specific immunogold labeling for FAM81 A protein at postsynaptic densities in the forebrain. The label for FAM81 A protein is concentrated at the cytoplasmic edge of the electron-dense core of the postsynaptic density, with a mean distance of ˜33 nm from the postsynaptic membrane. These observations firmly establish FAM81 A protein as a component of the postsynaptic density in the adult brain, suggesting a role in synaptic function.
This article was published in the following journal.
Name: Neuroscience letters
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