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In this paper, a reinforcement learning (RL)-based optimal adaptive control approach is proposed for the continuous infusion of a sedative drug to maintain a required level of sedation. To illustrate the proposed method, we use the common anesthetic drug propofol used in intensive care units (ICUs). The proposed online integral reinforcement learning (IRL) algorithm is designed to provide optimal drug dosing for a given performance measure that iteratively updates the control solution with respect to the pharmacology of the patient while guaranteeing convergence to the optimal solution. Numerical results are presented using 10 simulated patients that demonstrate the efficacy of the proposed IRL-based controller.
This article was published in the following journal.
Name: Mathematical biosciences
This paper investigates finite-horizon optimal consensus control problem for unknown multiagent systems with state delays. It is well known that optimal consensus control is the solutions to the coupl...
One major challenge to achieving optimal patient outcome in extracorporeal membrane oxygenation (ECMO) is the development of effective dosing strategies in this critically ill patient population. Subo...
This paper studies an optimal consensus tracking problem of heterogeneous linear multiagent systems. By introducing tracking error dynamics, the optimal tracking problem is reformulated as finding a N...
Odor cues and interoceptive cues can combine in promoting drug seeking behavior. Drug discrimination methodology was combined with odor-context conditioning in 8 male and 8 female rats. One drug (nico...
In this paper, event-triggered reinforcement learning-based adaptive tracking control is developed for the continuous-time nonlinear system with unknown dynamics and external disturbances. The critic ...
The overall aim of this study is to assess if patients with persistent GERD symptoms receiving sub-optimal omeprazole dosing experience improvement in GERD symptoms when prescribed an opti...
Purpose of the project is to examine the effectiveness of Reinforcement-Based Treatment (RBT) on drug abuse and psychosocial outcomes of iner city opiate abusers who have recently complete...
This is a pilot study evaluating the feasibility of using adaptive intermittent dosing of vemurafenib and cobimetinib in BRAF mutant patients with elevated baseline lactate dehydrogenase (...
This is a pilot study to develop a reinforcement learning (RL)-adaptive visual and interactive support application (hereafter RL-adaptive support) to help young adults with spina bifida or...
This is a double-blind, randomised, placebo-controlled, two-part adaptive clinical trial. The trial is designed to investigate the efficacy and safety of multiple dosing regimens of selepr...
Measurable biological parameters that serve for drug development, safety and dosing (DRUG MONITORING).
A component of the Executive Office of the President established by the Anti-Drug Abuse Act of 1988. The Office establishes policies, priorities, and objectives for national DRUG AND NARCOTIC CONTROL. The goals of the program are to reduce illicit drug use, manufacturing, and trafficking, drug-related crime and violence, and drug-related health consequences.
Control of drug and narcotic use by international agreement, or by institutional systems for handling prescribed drugs. This includes regulations concerned with the manufacturing, dispensing, approval (DRUG APPROVAL), and marketing of drugs.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Gated, ion-selective glycoproteins that traverse membranes. The stimulus for channel gating can be a membrane potential, drug, transmitter, cytoplasmic messenger, or a mechanical deformation. Ion channels which are integral parts of ionotropic neurotransmitter receptors are not included.
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...
Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...
Anesthesia is the loss of feeling or sensation in all or part of the body. It may result from damage to nerves or can be induced by an anesthetist (a medical professional) using anesthetics such as thiopental or propofol or sevoflurane during a surgical ...