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Oxycodone-Like Discriminative Stimulus Effects of Fentanyl-Related Emerging Drugs of Abuse in Mice.

07:00 EST 5th February 2019 | BioPortfolio

Summary of "Oxycodone-Like Discriminative Stimulus Effects of Fentanyl-Related Emerging Drugs of Abuse in Mice."

Fentanyl and its structurally related compounds have emerged as the most significant contributors to opioid overdose fatalities in recent years. While there is abundant information about the pharmacological effects of fentanyl, far less is known of its more recently abused analogs. The objective of this study was to determine whether fentanyl and several fentanyl-related substances would engender oxycodone-like responding in a mouse model of oxycodone discrimination. Oxycodone and fentanyl were selected as test compounds due to their high selectivity for mu opioid receptors. Compounds that elicited oxycodone-like responding in this procedure would likely evoke overlapping subjective experiences.

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Name: Neuropharmacology
ISSN: 1873-7064
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