Oxycodone-Like Discriminative Stimulus Effects of Fentanyl-Related Emerging Drugs of Abuse in Mice.

07:00 EST 5th February 2019 | BioPortfolio

Summary of "Oxycodone-Like Discriminative Stimulus Effects of Fentanyl-Related Emerging Drugs of Abuse in Mice."

Fentanyl and its structurally related compounds have emerged as the most significant contributors to opioid overdose fatalities in recent years. While there is abundant information about the pharmacological effects of fentanyl, far less is known of its more recently abused analogs. The objective of this study was to determine whether fentanyl and several fentanyl-related substances would engender oxycodone-like responding in a mouse model of oxycodone discrimination. Oxycodone and fentanyl were selected as test compounds due to their high selectivity for mu opioid receptors. Compounds that elicited oxycodone-like responding in this procedure would likely evoke overlapping subjective experiences.


Journal Details

This article was published in the following journal.

Name: Neuropharmacology
ISSN: 1873-7064


DeepDyve research library

PubMed Articles [25386 Associated PubMed Articles listed on BioPortfolio]

Effectiveness comparisons of G-protein biased and unbiased mu opioid receptor ligands in warm water tail-withdrawal and drug discrimination in male and female rats.

One emerging strategy to address the opioid crisis is the development of mu opioid receptor (MOR) ligands that preferentially signal the G-protein vs. β-arrestin pathway. The present study compared t...

Discriminative stimulus effects of mecamylamine and nicotine in rhesus monkeys: Central and peripheral mechanisms.

Mecamylamine is a non-competitive nicotinic acetylcholine receptor (nAChR) antagonist that has been prescribed for hypertension and as an off-label smoking cessation aid. Here, we examined pharmacolog...

Characterizing fentanyl-related overdoses and implications for overdose response: Findings from a rapid ethnographic study in Vancouver, Canada.

North America is experiencing an opioid overdose epidemic, fuelled by the proliferation of fentanyl, related analogues, and fentanyl-adulterated opioids. British Columbia, Canada has similarly experie...

Delta-opioid receptor antagonist naltrindole reduces oxycodone addiction and constipation in mice.

Oxycodone, a widely prescribed and very potent oral opioid analgesic agent, is highly addictive and has many side effects, including troublesome constipation. Our studies in mice indicated that pretre...

Fentanyl and fentanyl-analog involvement in drug-related deaths.

To describe and analyze the involvement of fentanyl and fentanyl analogs (FAs) in drug-related deaths in West Virginia (WV), United States.

Clinical Trials [5859 Associated Clinical Trials listed on BioPortfolio]

Oxycodone vs. Fentanyl in Early Postoperative Pain After Total Hip Replacement

Oxycodone is one of the most widely used opioids for pain treatment. Many studies demonstrated good efficacy of oxycodone on postoperative pain. In this study, we assess the efficacy and s...

Comparison of the Effects of Oxycodone Versus Fentanyl on Airway Reflex to Tracheal Extubation and Postoperative Pain

This study was performed to compare the effects of oxycodone and fentanyl on airway and hemodynamic responses and postoperative pain during recovery period in patients undergoing laparosco...

Herb-Opioid Interactions

This is a series of studies in healthy volunteers to assess the potential for adverse interactions between St. John's wort (SJW) extract and two narcotic (opioid) pain medications: oxycodo...

Oxycodone vs Fentanyl for Pain Treatment After Laparoscopic Cholecystectomy

To evaluate the analgesic efficacy of oxycodone and fentanyl in the treatment of postoperative pain after laparoscopic cholecystectomy.

Optimal Dose of Intravenous Oxycodone for Endotracheal Intubation

Intravenous form of oxycodone is recently used for the adjunct of anesthetic agents to avoid adverse effects of the stimulation of endotracheal intubation. The potency ratio of oxycodone t...

Medical and Biotech [MESH] Definitions

A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)

The tendency to react to stimuli that are different from, but somewhat similar to, the stimulus used as a conditioned stimulus.

The directional growth of an organism in response to an external stimulus such as light, touch, or gravity. Growth towards the stimulus is a positive tropism; growth away from the stimulus is a negative tropism. (From Concise Dictionary of Biology, 1990)

Learning that takes place when a conditioned stimulus is paired with an unconditioned stimulus.

The principle that after an organism learns to respond in a particular manner to a stimulus, that stimulus is effective in eliciting similar responses.

Quick Search


DeepDyve research library

Searches Linking to this Article