Cannabinoids differentially modulate the cortical information transmission through the sensorimotor or medial prefrontal basal ganglia circuits.

07:00 EST 8th February 2019 | BioPortfolio

Summary of "Cannabinoids differentially modulate the cortical information transmission through the sensorimotor or medial prefrontal basal ganglia circuits."

In the sensorimotor (SM) and medial prefrontal (mPF) basal ganglia (BG) circuits, the cortical information is transferred to the substantia nigra pars reticulata (SNr) through the hyperdirect trans-subthalamic pathway and through the direct and indirect trans-striatal pathways. The CB1 cannabinoid receptor, which is densely located in both BG circuits, may participate in the regulation of motor and motivational behaviours. Here, we investigated the modulation of cortico-nigral information transmission through the BG circuits by cannabinoids.


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This article was published in the following journal.

Name: British journal of pharmacology
ISSN: 1476-5381


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