H, C, and N resonance assignments of the cytokine interleukin-36β isoform-2.

07:00 EST 13th February 2019 | BioPortfolio

Summary of "H, C, and N resonance assignments of the cytokine interleukin-36β isoform-2."

Interleukins are cytokines performing central tasks in the human immune system. Interleukin-36β (IL-36β) is a member of the interleukin-1 superfamily as are its homologues IL-36α and IL-36γ. All of them interact with a common receptor composed of IL-36R and IL-1R/acP. IL-36 cytokines can activate IL-36R to proliferation of CD4 + lymphocytes or stimulate M2 macrophages as potently as IL-1β. Within our efforts to study the structure-function relationship of the three interleukins IL-36α, IL-36β and IL-36γ by heteronuclear multidimensional NMR, we here report the H, C, and N resonance assignments for the backbone and side chain nuclei of cytokine interleukin-36β isoform-2.


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Name: Biomolecular NMR assignments
ISSN: 1874-270X


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