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Samples of sputum, blood, bronchoalveolar lavage, swabs from the oropharynx from 255 military personnel undergoing in-patient treatment with an x-ray confirmed diagnosis of community-acquired pneumonia (CAP) were examined by polymerase chain reaction (PCR). The comparison group was included 270 healthy recruits. The detection of S. pneumoniae, H. influenzaе, M. pneumoniae, C. pneumoniae, C. psittaci, L. pneumophila, Adenovirus, Herpes symplex I/II, Cytomegalovirus was carried out by PCR using AmpliSens commercial test systems (CRIE) and GenPak DNA PCR test (Isogen LLC, Moscow). The etiologic factor of CAP for military personnel is set in 94.1% of cases. S. pneumoniae was the dominant pathogen of CAP. A high level of S. pneumoniae carriage (86.3%) among military personnel was shown. The incidence of M. pneumoniae was 14.5±2.2%, and C. pneumoniae was 13.7±2.2%. The highest detection rates of C. pneumoniae and M. pneumoniae were obtained in patients with not severe CAP - 16.2±2.6% и 16.7±2.7% of cases, respectively. The frequency of detection of these pathogens in patients with severe CAP was significantly lower - 5.3±3.0% and 7.0±3.4%, respectively (p<0.05). The role of L. pneumophila and C. psittaci was negligible. The frequency of detection of adenoviruses was 14,1±2,2% of cases, in particular, in patients with severe CAP - in 36.8±6.4% of cases. A high frequency of bacterial-bacterial and bacterial-viral associations has been established. In etiological CAP diagnostic in military personnel PCR is a highly effective method, especially during periods of high morbidity The high level of S. pneumoniae carriage among military personnel and its dominant role in the etiologic structure of the CAP indicate the need for specific immunization of new recruits. The significant contribution of M. pneumoniae and C. pneumoniae to the incidence of CAP confirm the advisability of their inclusion in the algorithm for the examination of patients with CAP. The high frequency of association of microorganisms indicates the need to take this fact into account when prescribing antibiotic therapy.
This article was published in the following journal.
Name: Klinicheskaia laboratornaia diagnostika
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Any infection acquired in the community, that is, contrasted with those acquired in a health care facility (CROSS INFECTION). An infection would be classified as community-acquired if the patient had not recently been in a health care facility or been in contact with someone who had been recently in a health care facility.
A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
A branch of medicine concerned with the total health of the individual within the home environment and in the community, and with the application of comprehensive care to the prevention and treatment of illness in the entire community.
The collective designation of three organizations with common membership: the European Economic Community (Common Market), the European Coal and Steel Community, and the European Atomic Energy Community (Euratom). It was known as the European Community until 1994. It is primarily an economic union with the principal objectives of free movement of goods, capital, and labor. Professional services, social, medical and paramedical, are subsumed under labor. The constituent countries are Austria, Belgium, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Netherlands, Portugal, Spain, Sweden, and the United Kingdom. (The World Almanac and Book of Facts 1997, p842)
Pneumonia caused by infection with bacteria of the family RICKETTSIACEAE.
Polymerase Chain Reaction (PCR)
PCR (Polymerase Chain Reaction) uses the ability of DNA polymerase (enzymes that create DNA molecules by assembling nucleotides, the building blocks of DNA. These enzymes are essential to DNA replication and usually work in pairs to create two ident...
Pneumonia (bronchopneumonia, lobar pneumonia and double pneumonia) is inflammation (swelling) of the tissue in one or both of your lungs. It is usually caused by an pneumococcal infection caused by bacteria called Streptococcus pneumoniae. However,...