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Hyaluronic acid (HA) is a natural biopolymer that can target to tumor cells due to CD44 receptors overexpressed in tumor cells. Here, a theranostic nanoparticle HA-Ce6 (DOX) with enzyme and pH dual-responsive is presented, which combined HA and a highly promised photosensitizer chlorin e6 (Ce6) using adipic dihydrazide (ADH) as a linker. The hydrazide group on its surface can efficiently conjugate doxorubicin to form HA-Ce6 (DOX) nanoparticles through the pH-sensitive hydrazone bond. In this study, the dual-response of HA-Ce6 (DOX) nanoparticles in the tumor cell are discussed. The HA-Ce6 (DOX) nanoparticles showed an average size of 90 nm with a uniform spherical morphology. In vitro drug release studies showed that HA-Ce6 (DOX) accomplished rapid drug release under acid conditions and enzyme stimulating. Confocal images revealed that the nanoparticles enhance the cellular accumulation of DOX and Ce6 in A549 cells. The therapeutic efficacy of HA-Ce6 (DOX) nanoparticles in A549 cells in vitro was evaluated through the MTT assay. The results showed that the therapeutic efficacy of HA-Ce6 (DOX) nanoparticles against A549 cells was remarkably enhanced compared with free DOX and free Ce6. These results indicate that the HA-Ce6 (DOX) nanoparticles could be a promising delivery system for photodynamic therapy and chemotherapy.
This article was published in the following journal.
Name: International journal of biological macromolecules
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Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.
Nanoparticles produced from metals whose uses include biosensors, optics, and catalysts. In biomedical applications the particles frequently involve the noble metals, especially gold and silver.
A layer of protein coating adsorbed by NANOPARTICLES upon entry into PLASMA or other protein-containing biological fluids, which affects how nanoparticles are internalized by cells and cleared from the body.
Materials such as COLLAGEN or HYALURONIC ACID that are injected or deposited into the DERMIS for the purpose of skin augmentation.
A group of high molecular weight chondroitin sulfate proteoglycans that form aggregates with HYALURONIC ACID.
Enzymes are proteins that catalyze (i.e., increase the rates of) chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical re...
Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...