Possible role of polycyclic aromatic hydrocarbons in the onset of melanoma : preliminary data.

07:00 EST 9th March 2019 | BioPortfolio

Summary of "Possible role of polycyclic aromatic hydrocarbons in the onset of melanoma : preliminary data."

Melanoma, a malignant neoplasm of melanocytic origin, is now considered a "health emergency" as it represents 4% of skin cancers and it is responsible for 80% of skin cancer deaths, corresponding to approximately 1%-2% of all cancer deaths. It is characterized by complex and heterogeneous etiopathogenesis in which are involved constitutional and environmental risk factors. Among these, an important role is played by air pollution. We examined all the cases of melanoma of the U.O.C. of Dermatology and STD of Palermo from 2016 to 2017, evaluated the ratio between incidence rate and residence of the patients, in order to identify the role of Polycyclic Aromatic Hydrocarbons in the incidence of melanoma. This article is protected by copyright. All rights reserved.


Journal Details

This article was published in the following journal.

Name: Journal of the European Academy of Dermatology and Venereology : JEADV
ISSN: 1468-3083


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Medical and Biotech [MESH] Definitions

Aromatic hydrocarbons that contain extended fused-ring structures.

A concave exterior region on some POLYCYCLIC AROMATIC HYDROCARBONS that have three phenyl rings in a non-linear arrangement.

Cytoplasmic proteins that bind certain aryl hydrocarbons, translocate to the nucleus, and activate transcription of particular DNA segments. AH receptors are identified by their high-affinity binding to several carcinogenic or teratogenic environmental chemicals including polycyclic aromatic hydrocarbons found in cigarette smoke and smog, heterocyclic amines found in cooked foods, and halogenated hydrocarbons including dioxins and polychlorinated biphenyls. No endogenous ligand has been identified, but an unknown natural messenger with a role in cell differentiation and development is suspected.


A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)

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