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A new pathway for naproxen utilisation by Bacillus thuringiensis B1(2015b) and its decomposition in the presence of organic and inorganic contaminants.

08:00 EDT 13th March 2019 | BioPortfolio

Summary of "A new pathway for naproxen utilisation by Bacillus thuringiensis B1(2015b) and its decomposition in the presence of organic and inorganic contaminants."

Bacillus thuringiensis B1 (2015b) is a bacterial strain that is able to degrade naproxen. However, the potential effect of water co-contaminations on the degradation process and its pathway have not yet been evaluated. The results of our study show that in the presence of aromatic compounds, the B1 (2015b) strain utilised naproxen with an efficiency that was similar to what it was with no aromatic co-contaminations. In the presence of methanol, biodegradation of naproxen was inhibited, while the addition of ethanol increased the decomposition of naproxen. Among the metal ions that were tested, only cobalt (II) and cadmium (II) negatively affected the degradation of the drug. An analysis of the intermediates and enzymes that are engaged in degrading naproxen revealed that the key metabolites are O-desmethylnaproxen, which is the product of tetrahydrofolate-dependent O-demethylase activity, and salicylic acid. Salicylic acid can then be hydroxylated to catechol or gentisic acid or can be cleaved to 2-oxo-3,5-heptadienedioic acid. The high activity level of catechol 1,2-dioxygenase indicated that the main degradative pathway of naproxen in the B1 (2015b) strain is via catechol cleavage.

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This article was published in the following journal.

Name: Journal of environmental management
ISSN: 1095-8630
Pages: 1-7

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Medical and Biotech [MESH] Definitions

A species of gram-positive bacteria which may be pathogenic for certain insects. It is used for the biological control of the Gypsy moth.

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A microaerophilic, LACTIC ACID producing species of Bacillus that occurs in fermented foods. It also produces ANTI-INFECTIVE AGENTS and is used as a PROBIOTIC.

A species of Bacillus that occurs in soil and marine sediments. Many strains are alkalophilic and able to metabolize HEAVY METALS; it may therefore be a useful species for ENVIRONMENTAL BIODEGRADATION.

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