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Numerous studies on γ-PGA production have investigated terrestrial renewable sources for reducing production costs, but there are no studies using waste marine resources so far. We aimed to develop a cost-effective production method of poly γ-D-glutamic acid (γ-D-PGA) by Bacillus sp. SJ-10 using green macroalgae (Ulva sp.) as a major substrate without hydrolysis pretreatment. The SJ-10 was shown to not only cause immediate tissue degradation of the Ulva membrane but also grew well as a sole substrate. The γ-D-PGA yield was 6.29 ± 0.34 g/L under optimized conditions via the response surface method (RSM), and the produced γ-D-PGA had a thermal decomposition temperature of 310 °C and molecular weight of 250-1780 kDa. The calculated cost efficiency for the final yield was 32% when compared with complex media. Therefore, the present study provided a strategy for promoting an ecofriendly and cost-effective means to produce γ-D-PGA via a marine renewable resource. This article is protected by copyright. All rights reserved.
This article was published in the following journal.
Name: Biotechnology and bioengineering
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