gene rearrangement: a powerful driver of β-catenin activation in liver tumours.

07:00 EST 2nd February 2019 | BioPortfolio

Summary of "gene rearrangement: a powerful driver of β-catenin activation in liver tumours."

We aimed at the identification of genetic alterations that may functionally substitute for mutation in ß-catenin-activated hepatocellular adenomas (HCAs) and hepatocellular carcinoma (HCC).


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This article was published in the following journal.

Name: Gut
ISSN: 1468-3288


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Medical and Biotech [MESH] Definitions

A catenin that binds F-ACTIN and links the CYTOSKELETON with BETA CATENIN and GAMMA CATENIN.

Ordered rearrangement of T-cell variable gene regions coding for the antigen receptors.

The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.

A multi-functional catenin that is highly homologous to BETA CATENIN. Gamma catenin binds CADHERINS and helps link their cytoplasmic tails to ACTIN in the CYTOSKELETON via ALPHA CATENIN. It is also found in DESMOSOMES where it mediates the link between DESMOSOMAL CADHERINS and DESMOPLAKIN.

Ordered rearrangement of B-lymphocyte variable gene regions coding for the IMMUNOGLOBULIN CHAINS, thereby contributing to antibody diversity. It occurs during the differentiation of the IMMATURE B-LYMPHOCYTES.

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Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...

Hepatology is the study of liver, gallbladder, biliary tree, and pancreas, and diseases associated with them. This includes viral hepatitis, alcohol damage, cirrhosis and cancer. As modern lifestyles change, with alcoholism and cancer becoming more promi...

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