Photophysical Properties Controlled by Substituents with Lone-Pair Electrons at the Ortho- or Para- Positions of Fluoroquinolone Antibiotics.

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Summary of "Photophysical Properties Controlled by Substituents with Lone-Pair Electrons at the Ortho- or Para- Positions of Fluoroquinolone Antibiotics."

The ortho- or para- substituents of NH2 or N-alkyl containing lone-pair electrons were found to change the energy levels and tran-sition configurations of the HOMO for some fluoroquinolone based antibiotics (FQs) and can significantly influence the electronic structure, intermolecular hydrogen bonding, internal conversion, fluorescence and intersystem crossing efficiencies of FQs in ace-tonitrile or aqueous solution after photoexcitation. These findings provide new insight that can help in the molecular design strate-gies to regulate the photophysical properties of photosensitive medicine, photodynamic therapy reagents, and energy conversion materials that contain similar aromatic carbonyl structures.


Journal Details

This article was published in the following journal.

Name: The journal of physical chemistry. B
ISSN: 1520-5207


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