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Correction to Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors.

08:00 EDT 22nd March 2019 | BioPortfolio

Summary of "Correction to Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors."

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Name: Journal of medicinal chemistry
ISSN: 1520-4804
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Medical and Biotech [MESH] Definitions

Bicyclic heterocyclic compounds containing a BENZENE ring fused to PYRIDAZINE.

Derivatives of QUINOLINES with fused PYRROLES and a keto group or INDOLEQUINONES with fused PIPERIDINES.

Compounds based on a seven-membered ring fused to a five-membered ring. Heat can rearrange them to NAPHTHALENES which have two fused six-membered rings. They are similar to guaiazulenes which are SESQUITERPENES with a six-membered ring fused to a five-membered ring.

The modification of the reactivity of ENZYMES by the binding of effectors to sites (ALLOSTERIC SITES) on the enzymes other than the substrate BINDING SITES.

Compounds with three fused rings that appear like a naphthalene fused to piperidone or like a benz(de)isoquinoline-1,3-dione (not to be confused with BENZYLISOQUINOLINES which have a methyl separating the naphthyl from the benzyl rings). Members are CYTOTOXINS.

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