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Human Antibody Bispecifics through Phage Display Selection.

08:00 EDT 22nd March 2019 | BioPortfolio

Summary of "Human Antibody Bispecifics through Phage Display Selection."

We developed a repertoire approach to generate human antibody bispecifics. Using phage display selection of antibody heavy chains in the presence of a competitor light chain and providing a cognate light chain with an affinity handle, we identified mutations that prevent heavy/light chain mispairing. The strategy allows for the selection of human antibody chains that autonomously assemble into bispecifics.

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This article was published in the following journal.

Name: Biochemistry
ISSN: 1520-4995
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