Neural basis of somatosensory target detection independent of uncertainty, relevance, and reports.

08:00 EDT 29th March 2019 | BioPortfolio

Summary of "Neural basis of somatosensory target detection independent of uncertainty, relevance, and reports."

Research on somatosensory awareness has yielded highly diverse findings with putative neural correlates ranging from activity within somatosensory cortex to activation of widely distributed frontoparietal networks. Divergent results from previous studies may reside in cognitive processes that often coincide with stimulus awareness in experimental settings. To scrutinise the specific relevance of regions implied in the target detection network, we used functional magnetic resonance imaging (n = 27) on a novel somatosensory detection task that explicitly controls for stimulus uncertainty, behavioural relevance, overt reports, and motor responses. Using Bayesian Model Selection, we show that responses reflecting target detection are restricted to secondary somatosensory cortex, whereas activity in insular, cingulate, and motor regions is best explained in terms of stimulus uncertainty and overt reports. Our results emphasise the role of sensory-specific cortex for the emergence of perceptual awareness and dissect the contribution of the frontoparietal network to classical detection tasks.


Journal Details

This article was published in the following journal.

Name: eLife
ISSN: 2050-084X


DeepDyve research library

PubMed Articles [21859 Associated PubMed Articles listed on BioPortfolio]

The uncertain brain: A co-ordinate based meta-analysis of the neural signatures supporting uncertainty during different contexts.

Uncertainty is often inevitable in everyday life and can be both stressful and exciting. Given its relevance to psychopathology and wellbeing, recent research has begun to address the brain basis of u...

Towards Establishing Age-Related Cortical Plasticity on the Basis of Somatosensation.

Age-related somatosensory processing appears to remain intact where tasks engage centrally- as opposed to peripherally-mediated mechanisms. This distinction suggests that insight into alterations in n...

Electrocorticographic changes in field potentials following natural somatosensory percepts in humans.

Restoration of somatosensory deficits in humans requires a clear understanding of the neural representations of percepts. To characterize the cortical response to naturalistic somatosensation, we exam...

Do theta oscillations explain the somatosensory change detection mechanism?

Recent research has indicated that the mismatch negativity (MMN) is elicited in response to a discernible small change of a somatosensory stimulus applied on the hand. However, the neural mechanism fo...

(Re)organisation of the somatosensory system after early brain lesion: a lateralization index fMRI study.

To evaluate the relationship between neural (re)organization of the somatosensory cortex and impairment of sensory function (2-point discrimination [2PD]) in individuals with unilateral cerebral palsy...

Clinical Trials [7188 Associated Clinical Trials listed on BioPortfolio]

Modulating Pain Using Transcranial Alternating Stimulation (tACS) in Healthy Human Subjects

Pain is a highly complex and subjective phenomenon which results from the dynamic integration of sensory and contextual (i.e. cognitive, emotional, and motivational) processes. Recent evid...

Computerized Cognitive Bias Intervention for Intolerance of Uncertainty

This investigation examines the efficacy of a brief, one-session computerized interpretation bias modification paradigm (CBM-I) in the reduction of intolerance of uncertainty. Intolerance ...

Functional Organization of Somatosensory Responses in the Secondary Somatosensitive Area and Insula

The implication of the second somatosensory area (SII) and the insular cortex in the processing of somatosensory inputs is now well established. However the functional anatomy of these are...

Effects of Kinesio Taping in Patients With Somatosensory Tinnitus

There is no specific treatment that can cure somatosensory tinnitus and usually conservative physical therapy modalities are used in the literature. The aim of the study is to investigate ...

Identifying the Neural Basis of Suicide Risk: Capability for Suicide and the Opioid System

Since capability for suicide involves overriding potential pain, and the opioid system plays a strong role in controlling pain perception, it follows that capability for suicide may be imp...

Medical and Biotech [MESH] Definitions

Disorders of sensory information received from superficial and deep regions of the body. The somatosensory system conveys neural impulses which pertain to proprioception, tactile sensation, thermal sensation, pressure sensation, and pain. PERIPHERAL NERVOUS SYSTEM DISEASES; SPINAL CORD DISEASES; and BRAIN DISEASES may be associated with impaired or abnormal somatic sensation.

A term used in Eastern European research literature for the functional neural unit that provides the basis for differential sensitivity; the analyzer consists of receptor, afferent nerves, and their central connections. (From Campbell's Psychiatric Dictionary, 8th ed.)

The phenomenon of antibody-mediated target cell destruction by non-sensitized effector cells. The identity of the target cell varies, but it must possess surface IMMUNOGLOBULIN G whose Fc portion is intact. The effector cell is a "killer" cell possessing Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent.

An early embryonic developmental process of CHORDATES that is characterized by morphogenic movements of ECTODERM resulting in the formation of the NEURAL PLATE; the NEURAL CREST; and the NEURAL TUBE. Improper closure of the NEURAL GROOVE results in congenital NEURAL TUBE DEFECTS.

Cells specialized to transduce mechanical stimuli and relay that information centrally in the nervous system. Mechanoreceptor cells include the INNER EAR hair cells, which mediate hearing and balance, and the various somatosensory receptors, often with non-neural accessory structures.

Quick Search


DeepDyve research library

Searches Linking to this Article