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Despite the great advances achieved in the Pauson-Khand reaction and the ever-increasing demand for fluorinated compounds, the use of vinyl fluorides as olefinic counterparts in the above-mentioned transformation had been completely overlooked. Herein, we describe, for the first time, the intramolecular Pauson-Khand reaction of enynes containing a vinyl fluoride moiety.
This article was published in the following journal.
Name: Organic letters
We report base mediated reactions of 1-bromo-2-(2,2-difluorovinyl)benzenes with phenols followed by Pd-catalyzed intramolecular C-H arylation, which offer a novel route to pharmaceutically relevant cl...
The transformation of hydroximoyl fluorides to nitrile oxides for [3 + 2]-cycloaddition with alkynes has been achieved for the first time. The hydroximoyl fluorides used in this work appeared to be no...
Concise total syntheses of (-)-indoxamycins A and B are reported. The chemistry features a 7-step preparation of a highly con-gested [5.5.6] tricyclic advanced common intermediate from a readily avail...
The development of new general methods for the synthesis of chiral fluorine-containing molecules is important for several scientific disciplines. By the Ir-catalyzed asymmetric hydrogenation of tri-su...
In this review, we summarize the current state-of-the-art regarding late transition-metal-catalyzed reactions of acyl fluorides, including their synthesis and transformations. In organic reactions, th...
The purpose of this study is to adapt depression prevention interventions of proven benefit to the primary care setting in a manner that would be acceptable and potentially available to yo...
The purpose of this trial is to evaluate the anticaries remineralizing potential of a toothpaste containing 500 ppm fluoride plus fTCP technology relative to a commercially available tooth...
Investigators hypothesized that the impact of surgery in terms of inducing a hypercoagulable state is more evident in morbidly obese pregnant women as opposed to their non-obese counterpar...
This is a Phase 2a safety/tolerably study to determine if there are clinically significant interactions between oral vigabatrin (gamma vinyl-gamma-amino butyric acid; VGB) concurrent with ...
The purpose of this study, then, is to search existing clinic and hospital records for answers to the following two questions: (1) Do pregnant women who are at least 37 weeks gestation an...
Fluorides, usually in pastes or gels, used for topical application to reduce the incidence of DENTAL CARIES.
Inorganic fluorides of tin. They include both stannic fluoride (tin tetrafluoride) and stannous fluoride (tin difluoride). The latter is used in the prevention of dental caries.
Compounds containing the vinyl (-C=CH2) functional group.
A nonmetallic, diatomic gas that is a trace element and member of the halogen family. It is used in dentistry as flouride (FLUORIDES) to prevent dental caries.
POLYMERS derived from the monomer VINYL COMPOUNDS.