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Site-Selective α-Alkoxyl Alkynation of Alkyl Esters Mediated by Boryl Radicals.

08:00 EDT 29th March 2019 | BioPortfolio

Summary of "Site-Selective α-Alkoxyl Alkynation of Alkyl Esters Mediated by Boryl Radicals."

A novel method for site-selective C-H functionalization of ethyl acetate mediated by pyridine-boryl radicals is presented, delivering a variety of 4-phenylbut-3-yn-2-yl acetate derivatives under mild conditions. A distinguishing feature of this reaction is that the pyridine-ligated boryl radicals can abstract the inactive α-hydrogen of the alkoxyl group instead of the α-hydrogen of carbonyl groups described in a previous report using amine-ligated boryl radicals. Significantly, substrates with halogen atoms are compatible under the reaction conditions.

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Name: Organic letters
ISSN: 1523-7052
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