NBE-Controlled Palladium-Catalyzed Interannular Selective C-H Silylation: Access to Divergent Silicon-Containing 1,1'-Biaryl-2-Acetamides.

08:00 EDT 29th March 2019 | BioPortfolio

Summary of "NBE-Controlled Palladium-Catalyzed Interannular Selective C-H Silylation: Access to Divergent Silicon-Containing 1,1'-Biaryl-2-Acetamides."

A novel palladium-catalyzed interannular selective C-H silylation of 1,1'-biaryl-2-acetamides is described. The combination of palladium catalyst with copper oxidant enables meta- or ortho-selective C-H silylation by employing hexamethyldisilane as a trimethylsilyl source, which relies on the control of NBE derivatives as a switch, thus providing straightforward access to divergent silicon-containing 1,1'-biaryl-2-acetamides.


Journal Details

This article was published in the following journal.

Name: Organic letters
ISSN: 1523-7052


DeepDyve research library

PubMed Articles [12097 Associated PubMed Articles listed on BioPortfolio]

Enantioselective Divergent Synthesis of C19-Oxo Eburnane Alkaloids via Palladium-Catalyzed Asymmetric Allylic Alkylation of an N-Alkyl-α, β-unsaturated Lactam.

The C19-oxo-functionalized eburnane alkaloids display unique chemical structure and interesting biological activity. Herein, we report a divergent enantioselective strategy to access these alkaloids b...

A Mild & Direct Site-Selective sp2 C-H Silylation of (Poly)Azines.

A base-mediated protocol that allows for the site-selective sp2 C-H silylation of azines is described. This method is distinguished by its mild conditions, simplicity and excel-lent site-selective mod...

Pd-Catalyzed Intramolecular Chemoselective C(sp2)-H and C(sp3)-H Activation of N-Alkyl- N-arylanthranilic Acids.

A controllable palladium-catalyzed intramolecular C-H activation of N-alkyl- N-arylanthranilic acids has been developed. The methodology allows selective synthesis of 1,2-dihydro-(4 H)-3,1-benzoxazin-...

Ru-Catalyzed Dehydrogenative Silylation of POSS-Silanols with Hydrosilanes: Its Introduction to One-Pot Synthesis.

A commercially available and stable ruthenium dodecacarbonyl catalyst (Ru(CO)) allows very efficient and convenient access to functionalized silsesquioxanes (SQs) containing siloxane moiety (Si-O-Si) ...

Umpolung Carbonyl Groups as Alkyl Organometallic Reagent Surrogates for Palladium Catalyzed Allylic Alkylation.

Palladium catalyzed allylic alkylation of non-stabilized carbon nucleophiles is difficult and still remains a major challenge. We report a direct palladium-catalyzed highly chemo- and regioselective C...

Clinical Trials [3503 Associated Clinical Trials listed on BioPortfolio]

Palladium-103 Seed Implant and Single Daily Dosing of Uroxatral Vs. Twice Daily Dosing of Flomax- A 3 Month Retrospective Efficacy Analysis

In the past ten years, newer drugs with more selective affinity for the alpha-receptor have been introduced. Alfuzosin (Uroxatral) and Tamulosin(Flomax are two second generation alpha-bloc...

Randomized Controlled Trial of Preoperative Alpha Blockade for Pheochromocytoma

Pheochromocytoma is a rare, catecholamine (ex. adrenaline) secreting tumor that requires preoperative alpha blockade to minimize intraoperative hemodynamic instability, thereby reducing in...

Selective Lobar Blockade and Bronchial Blockers

Selective lobar blockade (SLB) is a specific technique that allows collapse of the operated lobe during thoracic surgery while the other lobes are ventilated. It is associated with the imp...

Effect of Paracetamol on Renal Function in Plasmodium Knowlesi Malaria

Acute kidney injury is a common complication of severe Plasmodium knowlesi malaria, and an important contributor to mortality. The exact pathogenic mechanisms of AKI in knowlesi malaria a...

Carefully seLected and Easily Accessible at No Charge Medications Randomized Controlled Trial

This trial evaluates the effect of providing primary care patients with free and convenient access to a set of essential medicines. Half of the participants will receive free and convenien...

Medical and Biotech [MESH] Definitions

The fusion of ceramics (porcelain) to an alloy of two or more metals for use in restorative and prosthodontic dentistry. Examples of metal alloys employed include cobalt-chromium, gold-palladium, gold-platinum-palladium, and nickel-based alloys.

Implanted fluid propulsion systems with self-contained power source for providing long-term controlled-rate delivery of drugs such as chemotherapeutic agents or analgesics. Delivery rate may be externally controlled or osmotically or peristatically controlled with the aid of transcutaneous monitoring.

An Act that amends Title XVIII of the Social Security Act to repeal the Medicare sustainable growth rate, that strengthens Medicare access by improving physician payments, and that reauthorizes the Children's Health Insurance Program (CHIP).

Agreement in which author(s) and copyright holder(s) grant(s) to all users a free, irrevocable, worldwide, perpetual right of access to, and a license to copy, use, distribute, transmit and display the work publicly and to make and distribute derivative works, in any digital medium for any responsible purpose, subject to proper attribution of authorship, as well as the right to make small numbers of printed copies for their personal use. A complete version of the work and all supplemental materials, including a copy of the permission as stated above, in a suitable standard electronic format is deposited immediately upon initial publication in at least one online repository that is supported by an academic institution, scholarly society, government agency, or other well-established organization that seeks to enable open access, unrestricted distribution, interoperability, and long-term archiving. (from Bethesda Statement on Open Access Publishing)

Genetic defects in the selective or non-selective transport functions of the KIDNEY TUBULES.

Quick Search


DeepDyve research library

Searches Linking to this Article