Ni-catalyzed Reductive Deaminative Arylation at sp Carbon Centers.

08:00 EDT 29th March 2019 | BioPortfolio

Summary of "Ni-catalyzed Reductive Deaminative Arylation at sp Carbon Centers."

A Ni-catalyzed reductive deaminative arylation at unactivated sp carbon centers is described. This operationally simple and user-friendly protocol exhibits excellent chemoselectivity profile and broad substrate scope, thus complementing existing metal-catalyzed cross-coupling reactions to forge sp C-C linkages. These virtues have been assessed in the context of late-stage functionalization, hence providing a strategic advantage to reliably generate structure diversity with amine-containing drugs.


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Name: Organic letters
ISSN: 1523-7052


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