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The excited state dynamics and energetics of a series of BODIPY derived chromophores bound to a catechol at the boron position were investigated with a combination of static and time resolved spectroscopy, electrochemistry, and density functional theory calculations. Compared to the difluoro-BODIPY derived parent compounds, addition of the catechol at the boron reduced the excited state lifetime by three orders of magnitude. Deactivation of the excited state proceeded through an intermediate charge transfer state accessed from the initial optically excited π* state in less than one picosecond. Despite differences in structure of the BODIPY derivatives, and absorption maxima that spanned the visible portion of the spectrum, all compounds exhibited the same, rapid, excited state deactivation mechanism, suggesting generality of the observed dynamics within this class of compounds.
This article was published in the following journal.
Name: The journal of physical chemistry letters
A series of five boron dipyrromethene (BODIPY) bioconjugates containing an EGFR-targeted pegylated LARLLT peptide and/or an α-D-glucopyranose or biotin ethylene diamine group were synthesized and the...
A new hybrid cinnamoyl-coumarin probe was synthesised to study the formation and dynamics of a twisted internal charge transfer (TICT) excited state in homogeneous and biological membrane models. This...
We demonstrate pump-repump-probe (PRP) transient hole burning as a spectroscopic tool for differentiating reactive from non-reactive deactivation of excited photochemical reactants observed by transie...
Recent advances in experimental techniques have made it relatively easy to prepare reactant cations in well-defined states of electronic excitation. Extensive studies on the role of excited states in ...
As traditional phototherapy agents, boron dipyrromethene (BODIPY) photosensitizers have attracted increasing attention due to their high molar extinction coefficients, high phototherapy efficacy, and ...
RATIONALE: Boron neutron capture therapy may selectively kill tumor cells without harming normal tissue. PURPOSE: Phase II trial to study the effectiveness of boron neutron capture therap...
Boron Neutron Capture Therapy (BNCT) is an experimental radiation therapy technique that is based on the principle of irradiating boron atoms with neutrons. When neutrons have relatively l...
The purpose of the study is to investigate efficacy and safety boron neutron capture therapy (BNCT) administered in combination with cetuximab in the treatment of head and neck cancer that...
Boron Neutron Capture Therapy (BNCT) is an experimental radiation therapy technique which is based on the principle of irradiating boron atoms with neutrons. When neutrons have relatively ...
RATIONALE: Boron neutron capture therapy may selectively kill tumor cells without harming normal tissue. PURPOSE: This phase I trial is studying the side effects and best dose of boron ne...
A trace element with the atomic symbol B, atomic number 5, and atomic weight 10.81. Boron-10, an isotope of boron, is used as a neutron absorber in BORON NEUTRON CAPTURE THERAPY.
Inorganic or organic compounds that contain boron as an integral part of the molecule.
A technique for the treatment of neoplasms, especially gliomas and melanomas in which boron-10, an isotope, is introduced into the target cells followed by irradiation with thermal neutrons.
Emission of LIGHT when ELECTRONS return to the electronic ground state from an excited state and lose the energy as PHOTONS. It is sometimes called cool light in contrast to INCANDESCENCE. LUMINESCENT MEASUREMENTS take advantage of this type of light emitted from LUMINESCENT AGENTS.
An excited state of molecular oxygen generated photochemically or chemically. Singlet oxygen reacts with a variety of biological molecules such as NUCLEIC ACIDS; PROTEINS; and LIPIDS; causing oxidative damages.