α-Difluoromethylornithine suppresses inflammatory arthritis by impairing myeloid-derived suppressor cells.

08:00 EDT 27th March 2019 | BioPortfolio

Summary of "α-Difluoromethylornithine suppresses inflammatory arthritis by impairing myeloid-derived suppressor cells."

The chemopreventive drug α-difluoromethylornithine (DFMO) has been shown to have an antinociceptive effect on mechanical allodynia in inflammatory arthritis by directly inhibiting ornithine decarboxylase (ODC) and decreasing polyamine production in inflammatory sites. However, little is known about the effect of DFMO on the immune system of inflammatory arthritis. Here, we investigated the effect of DFMO in a well-established collagen-induced arthritis (CIA) mouse model and explored its effect on the immune system.


Journal Details

This article was published in the following journal.

Name: International immunopharmacology
ISSN: 1878-1705
Pages: 251-258


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