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Nef-mediated inhibition of NFAT following TCR stimulation differs between HIV-1 subtypes.

07:00 EST 21st February 2019 | BioPortfolio

Summary of "Nef-mediated inhibition of NFAT following TCR stimulation differs between HIV-1 subtypes."

Functional characterisation of different HIV-1 subtypes may improve understanding of viral pathogenesis and spread. Here, we evaluated the ability of 345 unique HIV-1 Nef clones representing subtypes A, B, C and D to inhibit NFAT signalling following TCR stimulation. The contribution of this Nef function to disease progression was also assessed in 211 additional Nef clones isolated from unique subtype C infected individuals in early or chronic infection. On average, subtype A and C Nef clones exhibited significantly lower ability to inhibit TCR-mediated NFAT signalling compared to subtype B and D Nef clones. While this observation corroborates accumulating evidence supporting relative attenuation of subtypes A and C that may paradoxically contribute to their increased global prevalence and spread, no significant correlations between Nef-mediated NFAT inhibition activity and clinical markers of HIV-1 infection were observed, indicating that the relationship between Nef function and pathogenesis is complex.

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This article was published in the following journal.

Name: Virology
ISSN: 1096-0341
Pages: 192-202

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