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Cells can communicate mechanically by responding to mechanical deformations generated by their neighbors. Here, we describe a new role for mechanical communication by demonstrating that mechanical coupling between cells acts as a signaling cue that reduces intrinsic noise in the interacting cells. We measure mechanical interaction between beating cardiac cells cultured on a patterned flexible substrate and find that beat-to-beat variability decays exponentially with coupling strength. To demonstrate that such noise reduction is indeed a direct consequence of mechanical coupling, we reproduce the exponential decay in an assay where a beating cell interacts mechanically with an artificial stochastic 'mechanical cell'. The mechanical cell consists of a probe that mimics the deformations generated by a stochastically beating neighboring cardiac cell. We show that noise reduction through mechanical coupling persists long after stimulation stops and identify microtubule integrity, NOX2, and CaMKII as mediators of noise reduction.
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In this paper, a two-stage filter for removing salt-and-pepper noise using noise detector based on characteristic difference parameter and adaptive directional mean filter is proposed. The first stage...
The statistical properties of the noise in the Mie lidar signal are analyzed by the statistical hypotheses testing method. Based on this, an adaptive filter is proposed to eliminate the noise. The lea...
Susceptibility weighted imaging (SWI) involves post-processing of gradient echo images which are sensitive to the spatial variations in magnetic susceptibility. The aim of this study is to develop an ...
An improved robust cubature Kalman filter (RCKF) based on variational Bayesian (VB) and transformed posterior sigma points error is proposed in this paper, which not only retains the robustness of RCK...
Image denoising has become a crucial task in medical ultrasound (US) imaging due to the presence of speckle or multiplicative noise and additive Gaussian noise. Recently, several denoising techniques ...
The purpose of the study is to determine if a more intensive application of communication intervention, i.e. 5 hours per week, will result in more frequent intentional communication acts, ...
This study was designed to assess the safety of retrieval of the Bard Recovery® G2® Filter System. The G2 filter is an FDA-cleared device for inferior vena caval interruption in patients...
The investigation is designed to verify that clinical use of the vena cava filter does not raise new questions of safety or effectiveness compared to currently-marketed permanent filters.
The effect of noise is often underestimated but it is one of the most common occupational health hazards. Its health effects include; noise-induced hearing loss, sleep disturbance, interfe...
The goal of this study is to determine the biomarkers of exposure and harm as well as the pattern of product purchase when ventilated vs. unventilated cigarettes are available in the marke...
Noise present in occupational, industrial, and factory situations.
Noise associated with transportation, particularly aircraft and automobiles.
The layer of EXTRACELLULAR MATRIX that lies between the ENDOTHELIUM of the glomerular capillaries and the PODOCYTES of the inner or visceral layer of the BOWMAN CAPSULE. It is the product of these two cell types. It acts as a physical barrier and an ion-selective filter.
Communication between animals involving the giving off by one individual of some chemical or physical signal, that, on being received by another, influences its behavior.
Hearing loss due to exposure to explosive loud noise or chronic exposure to sound level greater than 85 dB. The hearing loss is often in the frequency range 4000-6000 hertz.
An assay is an analytic procedure for qualitatively assessing or quantitatively measuring the presence or amount or the functional activity of a target entity. This can be a drug or biochemical substance or a cell in an organism or organic sample. ...