Track topics on Twitter Track topics that are important to you
Chronic inflammation within the coronary arteries with infiltration of macrophages into the endothelium results in atherosclerosis. Percutaneous coronary intervention (PCI) remains the standard of care for the treatment of most cases of atherosclerotic coronary artery disease (CAD). Intracoronary stents, either bare metal (BMS) or drug eluting (DES), can successfully treat luminal stenoses within the coronary arteries. Following successful PCI however, neointimal proliferation can develop within the deployed stent. Similar to the pathophysiology of native vessel atherosclerosis there is chronic inflammation within the neointima with infiltration of macrophages, a process called neoatherosclerosis, and can result in in-stent restenosis (ISR) and even acute thrombotic, coronary arterial occlusion following disruption of the neoatheroma. Neoatherosclerosis is a heterogeneous, pathobiological complication of PCI that can present more with angina recurrence or in its most extreme form with an acute coronary syndrome (ACS) In this review article, we will discuss possible mechanisms, clinical challenges, and the future therapies of neoatherosclerosis.
This article was published in the following journal.
Name: Thrombosis research
Neoatherosclerosis has emerged as a major cause of in-stent restenosis (ISR). Although this entity has been described as a unique process, optical coherence tomography (OCT) enables depiction of disti...
Research demonstrates that basic nursing care receives less attention in clinical settings and has become visually less prominent in nursing education curriculums. While much is known about the import...
Intrathecal (IT) delivery is useful in both basic research and clinical treatments. Here we aim to test a new minimally invasive distribution route to the subarachnoid space (SAS) and the flow of IT a...
Following nearly two decades of its conception, the phenomenon of oncogene addiction still represents a key concept of how progresses in basic research can translate to unprecedented translational bre...
What is the South-African concept of caring? In Africa, the principle of Ubuntu introduces the concept of belonging and caring. The purpose of this concept analysis was thus to analyze the concept of ...
This study aim to evaluate whether intensive lipid lowering therapy may improve the clinical outcomes in coronary artery disease patients with in-stent neoatherosclerosis, in comparison wi...
The aim of this study is to evaluate the relation among cholesterol uptake capacity which measure HDL functionality, neoathrosclerosis and target-lesion revascularization.
The aim of this study is to evaluate the efficacy of alirocumab for in-stent neoatherosclerosis by using optical coherence tomography, in comparison with standard statin therapy.
The aims of this study are - to confirm whether detrusor after-contraction (DAC) is a true contraction or not with a new approach - and to understand clinical implicatio...
This study aim is to evaluate the additional effect of eicosapentaenoic acid and dose up effect of rosuvastatin for neoatherosclerosis in coronary artery disease patients.
Pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Analysis of word concepts by the association of polar adjectives, e.g., good-bad, with the concept, father. The adjectives are usually scaled in 7 steps. The subject's placement of the concept on the adjectival scale indicates the connotative meaning of the concept.
One of several basic proteins released from EOSINOPHIL cytoplasmic granules. Eosinophil major basic protein is a 14-kDa cytotoxic peptide with a pI of 10.9. In addition to its direct cytotoxic effects, it stimulates the release of variety of INFLAMMATION MEDIATORS.
A group of 7 proteins produced from a single gene by alternate splicing found in central and peripheral nervous system myelin. The major basic protein (MBP) has long been of interest because it is the antigen, that, when injected into an animal, elicits a cellular immune response that produces the CNS autoimmune disease called experimental allergic encephalomyelitis (ENCEPHALOMYELITIS, ALLERGIC). In the peripheral nervous system, myelin basic protein 18.5-kDa is often referred to as the P1 protein. (From Siegel et al., Basic Neurochemistry, 5th ed, p130, 133)
Component of the NATIONAL INSTITUTES OF HEALTH. It supports and conducts research, both basic and clinical, on the normal and diseases nervous system. It was established in 1950.
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...
Acute Coronary Syndromes ACS
Acute Coronary Syndromes (ACS) is an umbrella term for situations where the blood supplied to the heart muscle is suddenly blocked. Treatment for acute coronary syndrome includes medicines and a procedure known as angioplasty, during which doctors inflat...