Multi-atlas based detection and localization (MADL) for location-dependent quantification of white matter hyperintensities.

08:00 EDT 13th March 2019 | BioPortfolio

Summary of "Multi-atlas based detection and localization (MADL) for location-dependent quantification of white matter hyperintensities."

The extent and spatial location of white matter hyperintensities (WMH) on brain MRI may be relevant to the development of cognitive decline in older persons. Here, we introduce a new method, known as the Multi-atlas based Detection and Localization (MADL), to evaluate WMH on fluid-attenuated inversion recovery (FLAIR) data. This method simultaneously parcellates the whole brain into 143 structures and labels hyperintense areas within each WM structure. First, a multi-atlas library was established with FLAIR data of normal elderly brains; and then a multi-atlas fusion algorithm was developed by which voxels with locally abnormal intensities were detected as WMH. At the same time, brain segmentation maps were generated from the multi-atlas fusion process to determine the anatomical location of WMH. Areas identified using the MADL method agreed well with manual delineation, with an interclass correlation of 0.97 and similarity index (SI) between 0.55 and 0.72, depending on the total WMH load. Performance was compared to other state-of-the-art WMH detection methods, such as BIANCA and LST. MADL-based analyses of WMH in an older population revealed a significant association between age and WMH load in deep WM but not subcortical WM. The findings also suggested increased WMH load in selective brain regions in subjects with mild cognitive impairment compared to controls, including the inferior deep WM and occipital subcortical WM. The proposed MADL approach may facilitate location-dependent characterization of WMH in older individuals with memory impairment.


Journal Details

This article was published in the following journal.

Name: NeuroImage. Clinical
ISSN: 2213-1582
Pages: 101772


DeepDyve research library

PubMed Articles [28294 Associated PubMed Articles listed on BioPortfolio]

Identification of protein subcellular localization via integrating evolutionary and physicochemical information into Chou's general PseAAC.

Identifying the location of proteins in a cell plays an important role in understanding their functions, such as drug design, therapeutic target discovery and biological research. However, the traditi...

An evaluation of atlas selection methods for atlas-based automatic segmentation in radiotherapy treatment planning.

Atlas-based automatic segmentation is used in radiotherapy planning to accelerate the delineation of organs at risk (OARs). Atlas selection has been proposed as a way to improve the accuracy and execu...

An iterative multi-atlas patch-based approach for cortex segmentation from neonatal MRI.

Brain structure analysis in the newborn is a major health issue. This is especially the case for preterm neonates, in order to obtain predictive information related to the child development. In partic...

Automatic brain labeling via multi-atlas guided fully convolutional networks.

Multi-atlas-based methods are commonly used for MR brain image labeling, which alleviates the burdening and time-consuming task of manual labeling in neuroimaging analysis studies. Traditionally, mult...

Motor unit innervation zone localization based on robust linear regression analysis.

With the aim of developing a flexible and reliable procedure for superficial muscle innervation zone (IZ) localization, we proposed a method to estimate IZ location using surface electromyogram (EMG) ...

Clinical Trials [9959 Associated Clinical Trials listed on BioPortfolio]

Alleviating Trunk Low Back Pain, With an Active Medical Device Study (ATLAS)

The aim of the study is to evaluate the reduction of pain by wearing the ATLAS Medical Device in standardized daily activities for patients with Chronic Low Back Pain. This is an interven...

Radioguided Occult Lesion Localisation by Indocyanine Green

Breast cancer is the most common cancer in women. It is the main cause of cancer deaths among women. The incidence of non-palpable tumors is estimated at 60%. Their better prognosis and th...

Radiofrequency Chip for Localization of Non-Palpable Breast Lesions

The purpose of the project is to compare Radiofrequency identification device (RFID) localization technique with the current clinical standard wire localization technique. The Investigator...

Diffusion Weighted MRI Accuracy in Cholesteatoma Localization

Magnetic resonance imaging of the middle ear has an increasing place in the therapeutic strategy in otology and especially for cholesteatoma. It is currently performed for complicated chol...

In Vivo Confocal Microscopy Tumor Atlas Study

This study aims to create an atlas based on the preliminary experience of the first feasibility study in neurosurgery. Hypothesis: That a confocal endomicroscope can be used during neurosu...

Medical and Biotech [MESH] Definitions

Ability to determine the specific location of a sound source.

A cyclic GMP-dependent protein kinase subtype that is expressed predominantly in INTESTINES, BRAIN, and KIDNEY. The protein is myristoylated on its N-terminus which may play a role its membrane localization.

A multi- and interdisciplinary field concerned with improving health and achieving equity in health for all people. It transcends national boundaries, promotes cooperation and collaboration within and beyond health science fields, and combines population-based disease prevention with individually-based patient care.

Detection of drugs that have been abused, overused, or misused, including legal and illegal drugs. Urine screening is the usual method of detection.

Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA or signs of INTRACRANIAL HYPERTENSION due to obstruction of the fourth ventricle. Common primary cerebellar tumors include fibrillary ASTROCYTOMA and cerebellar HEMANGIOBLASTOMA. The cerebellum is a relatively common site for tumor metastases from the lung, breast, and other distant organs. (From Okazaki & Scheithauer, Atlas of Neuropathology, 1988, p86 and p141)

Quick Search


DeepDyve research library

Relevant Topics

Radiology is the branch of medicine that studies imaging of the body; X-ray (basic, angiography, barium swallows), ultrasound, MRI, CT and PET. These imaging techniques can be used to diagnose, but also to treat a range of conditions, by allowing visuali...

Antiretroviral therapy
Standard antiretroviral therapy (ART) consists of the combination of at least three antiretroviral (ARV) drugs to maximally suppress the HIV virus and stop the progression of HIV disease. Huge reductions have been seen in rates of death and suffering whe...

Searches Linking to this Article