Clopidogrel as a Perpetrator of Drug-Drug Interactions: A Challenge for Quantitative Predictions?

08:00 EDT 30th March 2019 | BioPortfolio

Summary of "Clopidogrel as a Perpetrator of Drug-Drug Interactions: A Challenge for Quantitative Predictions?"

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Name: Clinical pharmacology and therapeutics
ISSN: 1532-6535


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Medical and Biotech [MESH] Definitions

The action of a drug that may affect the activity, metabolism, or toxicity of another drug.

Specific effects of drugs and substances on metabolic pathways such as those occurring through the CYTOCHROME P-450 ENZYME SYSTEM. These include effects that often result in DRUG INTERACTIONS; FOOD-DRUG INTERACTIONS; and HERB-DRUG INTERACTIONS.

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Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.

Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.

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