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Even viruses that are not pathogenic under normal conditions but instead have masked pathogenicity sometimes induce rare complications only in genetically susceptible hosts. These potentially pathogenic viruses can be identified by mice that are highly susceptible to viral infections, simulating the genetically susceptible condition of some humans. The proposed name of this approach is the 'Modified Brief Koch's Postulate', and this approach makes possible the highly sensitive identification of the potential disease-specific pathogenicity of viruses via animals carrying disease-specific susceptibility gene(s), which accurately mimic human virus-induced diseases. This approach is scientifically and clinically valid means of identifying viruses with masked pathogenicity. Moreover, this strategy will enhance the development of new vaccines against potentially pathogenic viruses. This article is protected by copyright. All rights reserved.
This article was published in the following journal.
Name: Journal of medical virology
Data on the susceptibility of influenza viruses from South Africa to neuraminidase inhibitors (NAIs) is scarce, and no extensive analysis was done.
Bees-including solitary, social, wild, and managed species-are key pollinators of flowering plant species, including nearly three-quarters of global food crops. Their ecological importance, coupled wi...
In May of 2018, virulent Newcastle disease virus was detected in sick, backyard, exhibition chickens in southern California. Since, the virus has affected 401 backyard and four commercial flocks, and ...
Viruses are ubiquitous and cause significant mortality in marine bacterial and archaeal communities. Little is known about the role of viruses in the sub-seafloor biosphere, which hosts a large fracti...
Low pathogenic avian influenza (LPAI) viruses can silently circulate in poultry and wild aquatic birds and potentially mutate into highly pathogenic avian influenza (HPAI) viruses. In the U.S., recent...
The highly pathogenic avian influenza (HPAI) H5N1 virus arrived in the Middle East in 2005 and has since established itself in local domestic birds and is now considered endemic in several...
The main focus of the study is : - To estimate seroprevalence of AI in poultry-exposed and non-exposed human populations. - To estimate the incidence of AI in poultry-exposed and n...
Inflammatory bowel diseases (IBD) are chronic inflammatory diseases. It is believed that the inflammation results from sustained abnormal immune response towards altered or pathogenic micr...
The purpose of this study is to investigate whether influenza can be reliably transmitted from children to susceptible contacts in a health care setting. The goal is to develop a transmiss...
The purpose of this study is to determine the percentage of patients with masked hypertension in a population with chronic kidney disease. The investigators goal is to register prospective...
A genus of potentially oncogenic viruses of the family POLYOMAVIRIDAE. These viruses are normally present in their natural hosts as latent infections. The virus is oncogenic in hosts different from the species of origin.
Viruses whose hosts are in the domain ARCHAEA.
A subtype of INFLUENZA A VIRUS that is highly virulent in poultry and wild birds, but shows varying degrees of pathogenicity in mice. The H5N8 virus subtype has a polybasic amino acid motif at the HA cleavage site which explains its pathogenicity in birds, and expresses surface proteins HEMAGGLUTININ 5 and NEURAMINIDASE 8 which are typical of Highly Pathogenic Avian Influenza viruses.
A collection of single-stranded RNA viruses scattered across the Bunyaviridae, Flaviviridae, and Togaviridae families whose common property is the ability to induce encephalitic conditions in infected hosts.
A family of RNA viruses infecting a broad range of animals. Most individual species are restricted to their natural hosts. They possess a characteristic six-pointed starlike shape whose surfaces have cup-shaped (chalice) indentions. Transmission is by contaminated food, water, fomites, and occasionally aerosolization of secretions. Genera include LAGOVIRUS; NORWALK-LIKE VIRUSES; SAPPORO-LIKE VIRUSES; and VESIVIRUS.
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...