Advertisement

Topics

Filamentous Hemagglutinin, a Model for the Two-Partner Secretion Pathway.

07:00 EST 1st March 2019 | BioPortfolio

Summary of "Filamentous Hemagglutinin, a Model for the Two-Partner Secretion Pathway."

Bacteria use a variety of mechanisms to translocate proteins from the cytoplasm, where they are synthesized, to the cell surface or extracellular environment or directly into other cells, where they perform their ultimate functions. Type V secretion systems (T5SS) use β-barrel transporter domains to export passenger domains across the outer membranes of Gram-negative bacteria. Distinct among T5SS are type Vb or two-partner secretion (TPS) systems in which the transporter and passenger are separate proteins, necessitating a mechanism for passenger-translocator recognition in the periplasm and providing the potential for reuse of the translocator. This review describes current knowledge of the TPS translocation mechanism, using filamentous hemagglutinin (FHA) and its transporter FhaC as a model. We present the hypothesis that the TPS pathway may be a general mechanism for contact-dependent delivery of toxins to target cells.

Affiliation

Journal Details

This article was published in the following journal.

Name: Microbiology spectrum
ISSN: 2165-0497
Pages:

Links

DeepDyve research library

PubMed Articles [16471 Associated PubMed Articles listed on BioPortfolio]

Caspse-11-GSDMD pathway is required for serum ferritin secretion in sepsis.

Ferritin is the major iron storage molecule of vertebrates, which can be detected in serum under numerous conditions, including inflammatory, neurodegenerative, and malignant diseases. Given this char...

A dyadic partner-schema model of relationship distress and depression: Conceptual integration of interpersonal theory and cognitive-behavioral models.

Difficulties in romantic relationships are a prominent part of the disorder for many individuals with depression. Researchers have called for an integration of interpersonal and cognitive-behavioral t...

Insulin increases cholesterol uptake, lipid droplet content, and apolipoprotein B secretion in CaCo-2 cells by upregulating SR-BI via a PI3K, AKT, and mTOR-dependent pathway.

The actions of insulin on intestinal cholesterol absorption and lipoprotein secretion are not well understood. Herein, we determined the effects of insulin on the levels of cholesterol transporter sca...

Accumulation of Eu(III) by Aspergillus sydowii and Trichoderma harzianum.

Radionuclides-resistant filamentous fungi were isolated from radionuclides' contaminated soils. Effects of contact time, mycelia dosage, pH, ionic strength and thiol compounds on Eu(III) accumulation ...

Electrical stimulation facilitates the angiogenesis of human umbilical vein endothelial cells through MAPK/ERK signaling pathway by stimulating FGF2 secretion.

Electrical stimulation (ES) is able to enhance angiogenesis by stimulating fibroblasts. Fibroblast growth factor 2 (FGF2) is an independent angiogenesis inducer. The current study aimed to evaluate th...

Clinical Trials [3704 Associated Clinical Trials listed on BioPortfolio]

Study to Improve Partner Services for STD Prevention

The goal of this study was to examine the efficacy of patient-delivered partner treatment (PDPT) compared to standard partner referral (PR) and booklet enhanced partner referral (BEPR).

Immunogenicity and Safety of Trivalent Recombinant Hemagglutinin Influenza Vaccine in Healthy Adults

The purpose of this study was to determine the dose-related safety, immunogenicity, and protective efficacy of a trivalent recombinant hemagglutinin influenza vaccine in healthy adults.

Control of Trichomoniasis

This study is designed to try to find the best method of partner notification and treatment for partners of women with trichomonas

Recombinant H7 Hemagglutinin Influenza Vaccine Trial

Recombinant H7 (rH7) vaccine has been shown to be poorly immunogenic in previous human clinical trials. This study will test approaches to improve the immunogenicity of H7 vaccine, namely ...

PrEP Implementation for Mothers in Antenatal Care

In a region with 15-20% HIV prevalence, an estimated 20% of HIV-uninfected women could have HIV exposures in pregnancy. In a theoretical scenario of perfect PrEP coverage, all women at ris...

Medical and Biotech [MESH] Definitions

Secretion systems of GRAM-NEGATIVE BACTERIA (single membrane proteins or multiprotein complexes) that carry out secretion of proteins from the PERIPLASMIC SPACE to the EXTRACELLULAR SPACE via a beta-barrel transmembrane pore. There are several T5SS subtypes: T5aSS monomeric autotransporters, T5bSS two-partner secretions systems (TPSS), T5cSS trimeric autotransporters, T5dSS fused two-partner secretion systems, and T5eSS autotransporters with inverted domains.

Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.

A series of sequential intracellular steps involved in the transport of proteins (such as hormones and enzymes) from the site of synthesis to outside the cell. The pathway involves membrane-bound compartments through which the newly synthesized proteins undergo POST-TRANSLATIONAL MODIFICATIONS, packaging, storage, or transportation to the PLASMA MEMBRANE for secretion.

A pattern of assaultive and coercive behavior by an individual against their partner or spouse that may include physical injury, psychological abuse, sexual assault, progressive isolation, stalking, deprivation, intimidation, and reproductive coercion.

A set of BACTERIAL ADHESINS and TOXINS, BIOLOGICAL produced by BORDETELLA organisms that determine the pathogenesis of BORDETELLA INFECTIONS, such as WHOOPING COUGH. They include filamentous hemagglutinin; FIMBRIAE PROTEINS; pertactin; PERTUSSIS TOXIN; ADENYLATE CYCLASE TOXIN; dermonecrotic toxin; tracheal cytotoxin; Bordetella LIPOPOLYSACCHARIDES; and tracheal colonization factor.

Advertisement
Quick Search
Advertisement
Advertisement

 


DeepDyve research library

Relevant Topic

Collaborations in biotechnology
Commercial and academic collaborations are used throughout the biotechnology and pharmaceutical sector to enhance research and product development. Collaborations can take the form of research and evaluation agreements, licensing, partnerships etc. ...


Searches Linking to this Article