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Lack of photographic documentation undermines assessment of hidradenitis suppurativa phenotypes: reply from the author.

08:00 EDT 29th March 2019 | BioPortfolio

Summary of "Lack of photographic documentation undermines assessment of hidradenitis suppurativa phenotypes: reply from the author."

We thank Dr van Straalen and Dr van der Zee for their response to our article. We agree that exploring genotype-phenotype correlation in inherited hidradenitis suppurativa (HS) is an important step in improving our understanding of the disease and optimizing patient care. We also acknowledge that as an 'exploratory' analysis there are limitations in our methodology of establishing phenotypes that are inherent in compiling limited clinical information with lack of face-to-face clinical examination. Future prospective, face-to-face studies are required to describe genotype-phenotype correlation and phenotypic inter-rater reliability (IRR) more accurately in a larger cohort of individuals, to dispute or confirm our preliminary findings. This article is protected by copyright. All rights reserved.

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This article was published in the following journal.

Name: The British journal of dermatology
ISSN: 1365-2133
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Medical and Biotech [MESH] Definitions

A chronic suppurative and cicatricial disease of the apocrine glands occurring chiefly in the axillae in women and in the groin and anal regions in men. It is characterized by poral occlusion with secondary bacterial infection, evolving into abscesses which eventually rupture. As the disease becomes chronic, ulcers appear, sinus tracts enlarge, fistulas develop, and fibrosis and scarring become evident.

The inflammation of a sweat gland (usually of the apocrine type). The condition can be idiopathic or occur as a result of or in association with another underlying condition. Neutrophilic eccrine hidradenitis is a relatively rare variant that has been reported in patients undergoing chemotherapy, usually for non-Hodgkin lymphomas or leukemic conditions.

The attempt to improve the PHENOTYPES of future generations of the human population by fostering the reproduction of those with favorable phenotypes and GENOTYPES and hampering or preventing BREEDING by those with "undesirable" phenotypes and genotypes. The concept is largely discredited. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

Production of a radiographic image of a small or very thin object on fine-grained photographic film under conditions which permit subsequent microscopic examination or enlargement of the radiograph at linear magnifications of up to several hundred and with a resolution approaching the resolving power of the photographic emulsion (about 1000 lines per millimeter).

The use of the GENETIC VARIATION of known functions or phenotypes to correlate the causal effects of those functions or phenotypes with a disease outcome.

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