Lack of photographic documentation undermines assessment of hidradenitis suppurativa phenotypes: reply from the author.

08:00 EDT 29th March 2019 | BioPortfolio

Summary of "Lack of photographic documentation undermines assessment of hidradenitis suppurativa phenotypes: reply from the author."

We thank Dr van Straalen and Dr van der Zee for their response to our article. We agree that exploring genotype-phenotype correlation in inherited hidradenitis suppurativa (HS) is an important step in improving our understanding of the disease and optimizing patient care. We also acknowledge that as an 'exploratory' analysis there are limitations in our methodology of establishing phenotypes that are inherent in compiling limited clinical information with lack of face-to-face clinical examination. Future prospective, face-to-face studies are required to describe genotype-phenotype correlation and phenotypic inter-rater reliability (IRR) more accurately in a larger cohort of individuals, to dispute or confirm our preliminary findings. This article is protected by copyright. All rights reserved.


Journal Details

This article was published in the following journal.

Name: The British journal of dermatology
ISSN: 1365-2133


DeepDyve research library

PubMed Articles [10610 Associated PubMed Articles listed on BioPortfolio]

Standardized Photographic Documentation of Hidradenitis Suppurativa/Acne Inversa.

Despite existing guidelines and methods for standardized clinical photography in dermatology and plastic surgery, human skin exhibits exquisite site-specific morphologies and functions, and each body ...

Hidradenitis suppurativa and associated diseases.

Hidradenitis suppurativa is a chronic, inflammatory, recurrent, debilitating skin disease characterized by recurrent abscesses, draining sinuses, and scarring, affecting principally areas of body fric...

Proceeding report of the Third Symposium on Hidradenitis Suppurativa Advances (SHSA) 2018.

The 3 Annual Symposium on Hidradenitis Suppurativa Advances (SHSA) took place on October 12-14, 2018 at the Women's College Hospital in Toronto, Ontario, Canada. This symposium was a joint meeting of ...

Infiltrative squamous cell carcinoma in hidradenitis suppurativa: A case report for early surgical intervention.

Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the skin that has potential for malignant transformation into squamous cell carcinoma (SCC). The pathogenesis of HS is poorly underst...

Comparative Overall Comorbidity Burden Among Patients With Hidradenitis Suppurativa.

The overall comorbidity burden among patients with hidradenitis suppurativa (HS) has not been systematically evaluated.

Clinical Trials [3529 Associated Clinical Trials listed on BioPortfolio]

Studying Complement Inhibition in Patients With Moderate to Severe Hidradenitis Suppurativa

The trial enrolls patients with moderate to severe Hidradenitis Suppurativa (HS). The primary goal of the trial is to evaluate the safety and tolerability of IFX-1 administered over 8 week...

Post-Marketing Surveillance of Adalimumab in Korean Hidradenitis Suppurativa Subjects

The objective of this study is to evaluate the safety profile of Adalimumab for Hidradenitis Suppurativa (HS) participants in normal medical practice.

A Randomized Controlled Trial Evaluating the Efficacy of Intralesional Triamcinolone in Hidradenitis Suppurativa.

Purpose: To evaluate the effectiveness of intralesional triamcinolone for the treatment of hidradenitis suppurativa Participants: Patients diagnosed with Hidradenitis Suppurativa that hav...

Study of Adalimumab in Subjects With Moderate to Severe Chronic Hidradenitis Suppurativa

This study will investigate how well adalimumab works in people with hidradenitis suppurativa (HS) in the short and long term.

Single Center Study of Apremilast for the Treatment of Hidradenitis Suppurativa

The primary objective of this study is to evaluate the safety and efficacy of Apremilast in subjects with moderate hidradenitis suppurativa (HS).

Medical and Biotech [MESH] Definitions

A chronic suppurative and cicatricial disease of the apocrine glands occurring chiefly in the axillae in women and in the groin and anal regions in men. It is characterized by poral occlusion with secondary bacterial infection, evolving into abscesses which eventually rupture. As the disease becomes chronic, ulcers appear, sinus tracts enlarge, fistulas develop, and fibrosis and scarring become evident.

The inflammation of a sweat gland (usually of the apocrine type). The condition can be idiopathic or occur as a result of or in association with another underlying condition. Neutrophilic eccrine hidradenitis is a relatively rare variant that has been reported in patients undergoing chemotherapy, usually for non-Hodgkin lymphomas or leukemic conditions.

The attempt to improve the PHENOTYPES of future generations of the human population by fostering the reproduction of those with favorable phenotypes and GENOTYPES and hampering or preventing BREEDING by those with "undesirable" phenotypes and genotypes. The concept is largely discredited. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

Production of a radiographic image of a small or very thin object on fine-grained photographic film under conditions which permit subsequent microscopic examination or enlargement of the radiograph at linear magnifications of up to several hundred and with a resolution approaching the resolving power of the photographic emulsion (about 1000 lines per millimeter).

The use of the GENETIC VARIATION of known functions or phenotypes to correlate the causal effects of those functions or phenotypes with a disease outcome.

Quick Search


DeepDyve research library

Searches Linking to this Article