Ventral midline thalamus lesion prevents persistence of new (learning-triggered) hippocampal spines, delayed neocortical spinogenesis, and spatial memory durability.

08:00 EDT 29th March 2019 | BioPortfolio

Summary of "Ventral midline thalamus lesion prevents persistence of new (learning-triggered) hippocampal spines, delayed neocortical spinogenesis, and spatial memory durability."

The ventral midline thalamus contributes to hippocampo-cortical interactions supporting systems-level consolidation of memories. Recent hippocampus-dependent memories rely on hippocampal connectivity remodeling. Remote memories are underpinned by neocortical connectivity remodeling. After a ventral midline thalamus lesion, recent spatial memories are formed normally but do not last. Why these memories do not endure after the lesion is unknown. We hypothesized that a lesion could interfere with hippocampal and/or neocortical connectivity remodeling. To test this hypothesis, in a first experiment male rats were subjected to lesion of the reuniens and rhomboid (ReRh) nuclei, trained in a water maze, and tested in a probe trial 5 or 25 days post-acquisition. Dendritic spines were counted in the dorsal hippocampus and medial prefrontal cortex. Spatial learning resulted in a significant increase of mushroom spines in region CA1. This modification persisted between 5 and 25 days post-acquisition in Sham rats, not in rats with ReRh lesion. Furthermore, 25 days after acquisition, the number of mushroom spines in the anterior cingulate cortex (ACC) had undergone a dramatic increase in Sham rats; ReRh lesion prevented this gain. In a second experiment, the increase of c-Fos expression in CA1 accompanying memory retrieval was not affected by the lesion, be it for recent or remote memory. However, in the ACC, the lesion had reduced the retrieval-triggered c-Fos expression observed 25 days post-acquisition. These observations suggest that a ReRh lesion might disrupt spatial remote memory formation by preventing persistence of early remodeled hippocampal connectivity, and spinogenesis in the ACC.


Journal Details

This article was published in the following journal.

Name: Brain structure & function
ISSN: 1863-2661


DeepDyve research library

PubMed Articles [8337 Associated PubMed Articles listed on BioPortfolio]

Ndfip Proteins Target Robo Receptors for Degradation and Allow Commissural Axons to Cross the Midline in the Developing Spinal Cord.

Commissural axons initially respond to attractive signals at the midline, but once they cross, they become sensitive to repulsive cues. This switch prevents axons from re-entering the midline. In inse...

Perforating foreign body in the ventriculus of a pet pigeon (Columba livia domestica).

CASE DESCRIPTION A 2-year-old female pigeon was evaluated because of a 5-day history of lower than typical activity level, weight loss, and polyuria. CLINICAL FINDINGS Whole-body radiography revealed ...

The brain of the tree pangolin (Manis tricuspis). V. The diencephalon and hypothalamus.

The diencephalon (dorsal thalamus, ventral thalamus and epithalamus) and the hypothalamus, plays central roles in the processing of the majority of neural information within the central nervous system...

The Cerebellar Thalamus.

The thalamus is a neural processor and integrator for the activities of the forebrain. Surprisingly, little is known about the roles of the "cerebellar" thalamus despite the anatomical observation tha...

Preproenkephalin-expressing ventral pallidal neurons control inhibitory avoidance learning.

The ventral pallidum (VP) is a critical component of the basal ganglia neurocircuitry regulating learning and decision making; however, its precise role in controlling associative learning of environm...

Clinical Trials [3298 Associated Clinical Trials listed on BioPortfolio]

Absorbable Versus Permanent Mesh Fixation Trial in Laparoscopic Midline Ventral Hernia Repair

To compare the use of absorbable tackers versus permanent tack fixation using a polyester large pore mesh in laparoscopic midline ventral hernia repair in a multicenter (Belgian) prospecti...

Anterior Component Separation Versus Posterior Component Separation for Repair of Large Ventral Hernias

This study evaluates effect of anterior component separation and posterior component separation and transversus abdominis muscle release methods for treatment of midline ventral hernias.

A Post-Market, Single-Arm Trial of XenMatrix™ AB Surgical Graft in Ventral or Incisional Midline Hernias

This study aims to prospectively explore the use of XenMatrix™ AB Surgical Graft for ventral or incisional midline hernia repair in patients across all wound classes ("All Comers") throu...

ProLOVE - Prospective Randomized Study of Midline Incisional Hernia Treatment

This purpose of this study is to compare the recovery after an operation of an incisional hernia within the limits of the rectus muscles of the abdominal wall. The use of a mesh in the rep...

Ultrasound in Deep Brain Stimulation

It is the purpose of this proposal to apply tFUS to the ventral posterior lateral (VPL) nucleus of the thalamus in humans.

Medical and Biotech [MESH] Definitions

Process in which individuals take the initiative, in diagnosing their learning needs, formulating learning goals, identifying resources for learning, choosing and implementing learning strategies and evaluating learning outcomes (Knowles, 1975)

A hernia caused by weakness of the anterior ABDOMINAL WALL due to midline defects, previous incisions, or increased intra-abdominal pressure. Ventral hernias include UMBILICAL HERNIA, incisional, epigastric, and spigelian hernias.

A region of the subthalamus located ventral to the THALAMUS and dorsal to the SUBTHALAMIC NUCLEUS.

A large group of nuclei lying between the internal medullary lamina and the internal capsule. It includes the ventral anterior, ventral lateral, and ventral posterior nuclei.

Circumventricular cellular structure in the anterior hypothalamic region. It is located in the optic recess at the anteroventral end of the THIRD VENTRICLE and forms the ventral part of the midline anterior wall.

Quick Search


DeepDyve research library

Relevant Topic

Mergers & Acquisitions
Commercial and market reports on mergers and acquisitions in the biotechnology, pharmaceutical, medical device and life-science industries. Mergers and acquisitions (abbreviated M&A;) is an aspect of corporate strategy, corporate finance and manageme...

Searches Linking to this Article