Advertisement

Topics

Polymer translocation through a hairy channel mimicking the inner plug of a nuclear pore complex.

08:00 EDT 29th March 2019 | BioPortfolio

Summary of "Polymer translocation through a hairy channel mimicking the inner plug of a nuclear pore complex."

A microscopic transport model of a polymer translocating through a nuclear pore complex (NPC) is presented based on self-consistent field theory (SCFT), with the NPC and its nucleoporins mimicked by a hairy channel. Multiple cell environment effects (electrolyte effect, excluded volume effect, NPC drag effect, and hydrophobic effect) are all considered in this hairy channel model. The influence of various parameters (polymer chain length, length of NPC, strength of hydrophobic effect, and excluded volume effect) on translocation time is studied through theoretical analysis and numerical calculation. Numerical simulation results show that an area of low nucleoporin number density exists in the NPC, which facilitates the translocation of the polymer. The results also show that the translocation time curves with increasing NPC length and polymer charge number are concave. In addition, there are critical values for NPC length and polymer charge number for which the translocation time has a minimal value. The translocation time decreases with the increasing strength of the hydrophobic effect and excluded volume effect.

Affiliation

Journal Details

This article was published in the following journal.

Name: European biophysics journal : EBJ
ISSN: 1432-1017
Pages:

Links

DeepDyve research library

PubMed Articles [4687 Associated PubMed Articles listed on BioPortfolio]

False lumen occlusion in chronic aortic dissection: the new generation Candy-Plug II.

To introduce the new generation Candy-Plug II with a self-closing channel construction inside the plug.

Translocation Dynamics Of An Asymmetrically Charged Polymer Through A Pore Under The Influence Of Different pH Conditions.

We study the translocation of a polymer with oppositely charged segments at both ends of the chain passing through a pore under the effect of an external electric field in the presence of a pH gradien...

Protein translocation by the SecA ATPase occurs by a power-stroke mechanism.

SecA belongs to the large class of ATPases that use the energy of ATP hydrolysis to perform mechanical work resulting in protein translocation across membranes, protein degradation, and unfolding. Sec...

Roles of the hydrophobic gate and exit channel in Vigna radiata pyrophosphatase ion translocation.

Membrane-embedded pyrophosphatase (M-PPase) hydrolyzes pyrophosphate to drive ion (H and/or Na) translocation. We determined crystal structures and functions of Vigna radiata M-PPase (VrH-PPase), the ...

Spectral Sensor Inspired by Cone Photoreceptors and Ion Channels without External Power.

In this study, we focused the mimicking of the cone photoreceptor along with ion channel system which is similar with real optical system. By realizing the ion channel and photoreceptor based on photo...

Clinical Trials [660 Associated Clinical Trials listed on BioPortfolio]

Treatment and Suppression of Hairy Leukoplakia in ARC Patients With Oral Acyclovir (ACV)

To evaluate the efficacy of oral acyclovir for the treatment and suppression of Epstein-Barr virus (EBV) related hairy leukoplakia (HL). To determine the long-term safety of acyclovir in t...

Ibrutinib in Treating Patients With Relapsed Hairy Cell Leukemia

This phase II trial studies how well ibrutinib works in treating patients with relapsed hairy cell leukemia. Ibrutinib may stop the growth of cancer cells by blocking some of the enzymes n...

Rituximab in Hairy Cell Leukemia: a Multicenter Retrospective Study

Hairy-cell leukemia is a rare and indolent lymphoid disorder, representing 2% of all cases of lymphoid leukemias. Treatment of hairy-cell leukemia relies mainly on the purine analogs, clad...

Evaluation of the Bio-Seal Biopsy Track Plug

The purpose of this study is to demonstrate safety and effectiveness of the Bio-Seal Biopsy Track Plug in a clinical setting for use in lung biopsy procedures to reduce the rate of air lea...

Daily or Weekly Cladribine in Treating Patients With Hairy Cell Leukemia

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known if giving cladribine once a day is more effectiv...

Medical and Biotech [MESH] Definitions

Strongly cationic polymer that binds to certain proteins; used as a marker in immunology, to precipitate and purify enzymes and lipids. Synonyms: aziridine polymer; Epamine; Epomine; ethylenimine polymer; Montrek; PEI; Polymin(e).

Epithelial hyperplasia of the oral mucosa associated with Epstein-Barr virus (HERPESVIRUS 4, HUMAN) and found almost exclusively in persons with HIV infection. The lesion consists of a white patch that is often corrugated or hairy.

The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.

A neoplastic disease of the lymphoreticular cells which is considered to be a rare type of chronic leukemia; it is characterized by an insidious onset, splenomegaly, anemia, granulocytopenia, thrombocytopenia, little or no lymphadenopathy, and the presence of "hairy" or "flagellated" cells in the blood and bone marrow.

Infection with human herpesvirus 4 (HERPESVIRUS 4, HUMAN); which may facilitate the development of various lymphoproliferative disorders. These include BURKITT LYMPHOMA (African type), INFECTIOUS MONONUCLEOSIS, and oral hairy leukoplakia (LEUKOPLAKIA, HAIRY).

Advertisement
Quick Search
Advertisement
Advertisement

 


DeepDyve research library

Searches Linking to this Article