Cortisol Stress Response and in Vivo PET Imaging of Human Brain Serotonin 1A Receptor Binding.

08:00 EDT 28th March 2019 | BioPortfolio

Summary of "Cortisol Stress Response and in Vivo PET Imaging of Human Brain Serotonin 1A Receptor Binding."

Abnormalities in the hypothalamic-pituitary-adrenal axis, serotonergic system, and stress response have been linked to the pathogenesis of major depressive disorder. State-dependent hyper-reactivity of the hypothalamic-pituitary-adrenal axis is seen in major depressive disorder, and higher binding to the serotonin 1A receptor is observed as a trait in both currently depressed and remitted untreated major depressive disorder. Here, we sought to examine whether a relationship exists between cortisol secretion in response to a stressor and serotonin 1A receptor binding throughout the brain, both in healthy controls and participants with major depressive disorder.


Journal Details

This article was published in the following journal.

Name: The international journal of neuropsychopharmacology
ISSN: 1469-5111


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