Eco-friendly Evaluation of Rifaximin in Tablets by Capillary Electrophoresis.

08:00 EDT 30th March 2019 | BioPortfolio

Summary of "Eco-friendly Evaluation of Rifaximin in Tablets by Capillary Electrophoresis."

Rifaximin, an oral antimicrobial, has no standardized analytical methods in many official compendia. In this context, the aim was to develop and validate an analytical method by capillary electrophoresis for quantification of rifaximin in tablets. The choice of capillary electrophoresis was based on the concepts of green analytical chemistry, taking into account the health of the operator and environment, analytical conscience, as well as the parameters of linearity, selectivity, precision, accuracy and robustness. The method was linear between 50 and 500 μg mL-1 (r = 0.9993) using purified water and ethanol in the sample preparation, silica capillary, borate buffer 25 mM pH 9.5, 20 kV and 290 nm. It presented good precision intraday (1.30%) and interday (1.56%). The accuracy complied with average recovery of 100.24%, as well as selectivity in the presence of impurities and degradation products and robustness against variations in the concentration, pH, rinse time of the buffer, voltage, wavelength, injection time and temperature. The capillary electrophoresis method developed for the evaluation of rifaximin tablets is low cost, fast, miniaturized, clean and environmentally friendly and can be used by laboratories and chemical and pharmaceutical industries for quality control of the drug.


Journal Details

This article was published in the following journal.

Name: Journal of chromatographic science
ISSN: 1945-239X


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Medical and Biotech [MESH] Definitions

A separation technique which combines LIQUID CHROMATOGRAPHY and CAPILLARY ELECTROPHORESIS.

A highly-sensitive (in the picomolar range, which is 10,000-fold more sensitive than conventional electrophoresis) and efficient technique that allows separation of PROTEINS; NUCLEIC ACIDS; and CARBOHYDRATES. (Segen, Dictionary of Modern Medicine, 1992)

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Electrophoresis in which a second perpendicular electrophoretic transport is performed on the separate components resulting from the first electrophoresis. This technique is usually performed on polyacrylamide gels.

A highly miniaturized version of ELECTROPHORESIS performed in a microfluidic device.

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