Advertisement

Topics

Hydrogen sulfide: a gaseous signaling molecule modulates tissue homeostasis: implications in ophthalmic diseases.

08:00 EDT 29th March 2019 | BioPortfolio

Summary of "Hydrogen sulfide: a gaseous signaling molecule modulates tissue homeostasis: implications in ophthalmic diseases."

Hydrogen sulfide (HS) serves as a gasotransmitter in the regulation of organ development and maintenance of homeostasis in tissues. Its abnormal levels are associated with multiple human diseases, such as neurodegenerative disease, myocardial injury, and ophthalmic diseases. Excessive exposure to HS could lead to cellular toxicity, orchestrate pathological process, and increase the risk of various diseases. Interestingly, under physiological status, HS plays a critical role in maintaining cellular physiology and limiting damages to tissues. In mammalian species, the generation of HS is catalyzed by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), 3-mercapto-methylthio pyruvate aminotransferase (3MST) and cysteine aminotransferase (CAT). These enzymes are found inside the mammalian eyeballs at different locations. Their aberrant expression and the accumulation of substrates and intermediates can change the level of HS by orders of magnitude, causing abnormal structures or functions in the eyes. Detailed investigations have demonstrated that HS donors' administration could regulate intraocular pressure, protect retinal cells, inhibit oxidative stress and alleviate inflammation by modulating the function of intra or extracellular proteins in ocular tissues. Thus, several slow-releasing HS donors have been shown to be promising drugs for treating multiple diseases. In this review, we discuss the biological function of HS metabolism and its application in ophthalmic diseases.

Affiliation

Journal Details

This article was published in the following journal.

Name: Cell death & disease
ISSN: 2041-4889
Pages: 293

Links

DeepDyve research library

PubMed Articles [17595 Associated PubMed Articles listed on BioPortfolio]

Role of hydrogen sulfide in the musculoskeletal system.

Hydrogen sulfide (HS) has been known as a gasotransmitter, and it contributes to various physiological and pathological processes. Multiple enzymes such as cystathionine-β-synthase (CBS), cystathioni...

Hydrogen sulfide-mediated regulation of cell death signaling ameliorates adverse cardiac remodeling and diabetic cardiomyopathy.

The death of cardiomyocytes is a precursor for the cascade of hypertrophic and fibrotic remodeling that leads to cardiomyopathy. In diabetes mellitus (DM), the metabolic environment of hyperglycemia, ...

Hydrogen sulfide directs metabolic flux towards the lignan biosynthesis in Linum album hairy roots.

Hydrogen sulfide (HS) has been recently found as an important signaling molecule especially in root system architecture of plants. The regulation of root formation through HS has been reported in prev...

Periodic deprivation of gaseous hydrogen sulfide affects the activity of the concrete corrosion layer in sewers.

Sulfide induced concrete corrosion significantly reduces the service life of the sewer systems. Gaseous hydrogen sulfide (HS) levels are a key factor affecting the corrosion rate and these fluctuate d...

Signaling by hydrogen sulfide (HS) and polysulfides (HS) in the central nervous system.

Hydrogen sulfide (HS) is a signaling molecule used to modify neuronal transmission, regulate vascular tone, protect tissues from oxidative stress, sense oxygen, and generate ATP. Hydrogen polysulfides...

Clinical Trials [4090 Associated Clinical Trials listed on BioPortfolio]

Plasma Hydrogen Sulfide, Nitric Oxide and Stress Hyperglycemia in Acute Myocardial Infarction

Acute myocardial infarction (AMI) can cause heart failure, an irregular heartbeat, cardiogenic shock, or cardiac arrest. It is the major cause of morbidity and mortality in the general pop...

Hydrogen Sulfide Production by Oral Microflora

Oral malodor is a common condition. In most cases this condition results from the proteolytic activity of anaerobic oral bacteria. These bacteria produce volatile sulfide compounds which a...

Combination of Dental Bleaching Techniques, Randomized Clinical Trial

To determine the effectiveness of combining different concentrations of hydrogen peroxide and carbamide used during tooth bleaching.

Therapeutic Effects of Hydrogen on Steroid-refractory/or Steroid-dependent cGVHD

This study suggested that hydrogen has a potential as an effective and safe therapeutic agent on cGVHD.

Selenium Sulfide, Ketoconazole and Ciclopirox Shampoo as Additional Treatments for Tinea Capitis (Scalp Ringworm)

Antifungal shampoos have been used as supplements to oral griseofulvin to help eradicate tinea capitis (also known as ringworm of the scalp) more quickly. While selenium sulfide shampoo h...

Medical and Biotech [MESH] Definitions

A combustible, gaseous mixture of low-molecular weight PARAFFIN hydrocarbons, generated below the surface of the earth. It contains mostly METHANE and ETHANE with small amounts of PROPANE; BUTANES; and higher hydrocarbons, and sometimes NITROGEN; CARBON DIOXIDE; HYDROGEN SULFIDE; and HELIUM. (from McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

A NADPH-dependent oxidase that reduces hydrogen sulfite to HYDROGEN SULFIDE. It is found in many microoganisms.

A crystalline compound used as a laboratory reagent in place of HYDROGEN SULFIDE. It is a potent hepatocarcinogen.

A genus of phototrophic, obligately anaerobic bacteria in the family Chlorobiaceae. They are found in hydrogen sulfide-containing mud and water environments.

Inert liquid or gaseous halocarbon compounds in which FLUORINE replaces some or all HYDROGEN atoms.

Advertisement
Quick Search
Advertisement
Advertisement

 


DeepDyve research library

Relevant Topic

Ophthalmology
Ophthalmology is the branch of medicine that is devoted to the study and treatment of eye diseases. As well as mild visual defects correctable by lenses, ophthalmology is concerned with glaucoma, uveitis and other serious conditions affecting the eye, ...


Searches Linking to this Article