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A novel imaging flow cytometry method for the detection of histone H4 acetylation in myeloid cells.

08:00 EDT 31st March 2019 | BioPortfolio

Summary of "A novel imaging flow cytometry method for the detection of histone H4 acetylation in myeloid cells."

The Histone deacetylase inhibitor (HDACI) valproic acid has been shown to inhibit the growth of multiple paediatric tumour types and is well tolerated in a childhood cancer setting. The current study was designed to develop a novel imaging flow cytometry method for the detection of histone H4 acetylation in white blood cells obtained from childhood cancer patients treated with valproic acid.

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Journal Details

This article was published in the following journal.

Name: European journal of clinical investigation
ISSN: 1365-2362
Pages: e13115

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Medical and Biotech [MESH] Definitions

The specific patterns of POST-TRANSLATIONAL PROTEIN MODIFICATION of HISTONES, i.e. histone ACETYLATION; METHYLATION; PHOSPHORYLATION; and ubiquitination, at specific amino acid residues, that are involved in assembly, maintenance, and modification of different chromatin structural states, such as EUCHROMATIN and HETEROCHROMATIN.

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