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Low Dose PET Emulation from Decimated High Statistics: A Clinical Validation Study.

08:00 EDT 31st March 2019 | BioPortfolio

Summary of "Low Dose PET Emulation from Decimated High Statistics: A Clinical Validation Study."

The fundamental nature of PET, as an event detection system, provides some flexibility for data handling, including retrospective data manipulation. The reorganization of acquisition data allows the emulation of new scans arising from identical radiotracer spatial distributions, but with different statistical compositions, and is especially useful for evaluating the stability and reproducibility of reconstruction algorithms or when investigating extremely low count conditions. This approach is ubiquitous in the research literature but has only been validated, from the point of view of the noise properties, with numerical simulations and phantom data. We present here the first experiment comparing PET images of the same human subjects generated with two separate injections of radiotracer, using actual low dose data to validate a randomly decimated emulation from a standard dose scan. A key point of the work is focused on the randoms fractions, which scale differently than the trues at varying activity levels.

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Name: Medical physics
ISSN: 2473-4209
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