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Physical principles and functional consequences of nuclear compartmentalization in budding yeast.

08:00 EDT 28th March 2019 | BioPortfolio

Summary of "Physical principles and functional consequences of nuclear compartmentalization in budding yeast."

One striking feature of eukaryotic nuclei is the existence of discrete regions, in which specific factors concentrate while others are excluded, thus forming microenvironments with different molecular compositions and biological functions. These domains are often referred to as subcompartments even though they are not membrane enclosed. Despite their functional importance the physical nature of these structures remains largely unknown. Here, we describe how the Saccharomyces cerevisiae nucleus is compartmentalized and discuss possible physical models underlying the formation and maintenance of chromatin associated subcompartments. Focusing on three particular examples, the nucleolus, silencing foci, and repair foci, we discuss the biological implications of these different models as well as possible approaches to challenge them in living cells.

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This article was published in the following journal.

Name: Current opinion in cell biology
ISSN: 1879-0410
Pages: 105-113

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