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Comparative solution and structural studies of half-sandwich rhodium and ruthenium complexes bearing curcumin and acetylacetone.

07:00 EST 28th February 2019 | BioPortfolio

Summary of "Comparative solution and structural studies of half-sandwich rhodium and ruthenium complexes bearing curcumin and acetylacetone."

Half-sandwich organometallic complexes of curcumin are extensively investigated as anticancer compounds. Speciation studies were performed to explore the solution stability of curcumin complexes formed with [Rh(η-CMe)(HO)]. Acetylacetone (Hacac), as the simplest β-diketone ligand bearing (O,O) donor set, was involved for comparison and its Ru(η‑p‑cymene), Ru(η‑toluene) complexes were also studied. H NMR, UV-visible and pH-potentiometric titrations revealed a clear trend of stability constants of the acac complexes: Ru(η‑p‑cymene) > Ru(η‑toluene) > Rh(η-CMe). Despite this order, the highest extent of complex formation is seen for the Rh(η-CMe) complexes at pH 7.4. Formation constant of [Rh(η-CMe)(Hcurcumin)(HO)] reveals similar solution stability to that of the acac complex. Additionally, structures of two complexes were determined by X-ray crystallography. The in vitro cytotoxicity of curcumin was not improved by the complexation with these organometallic cations.

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This article was published in the following journal.

Name: Journal of inorganic biochemistry
ISSN: 1873-3344
Pages: 91-100

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Medical and Biotech [MESH] Definitions

Unstable isotopes of ruthenium that decay or disintegrate emitting radiation. Ru atoms with atomic weights 93-95, 97, 103, and 105-108 are radioactive ruthenium isotopes.

Rhodium. A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh. (Dorland, 28th ed)

Inorganic compounds that contain ruthenium as an integral part of the molecule.

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