Comparative solution and structural studies of half-sandwich rhodium and ruthenium complexes bearing curcumin and acetylacetone.

07:00 EST 28th February 2019 | BioPortfolio

Summary of "Comparative solution and structural studies of half-sandwich rhodium and ruthenium complexes bearing curcumin and acetylacetone."

Half-sandwich organometallic complexes of curcumin are extensively investigated as anticancer compounds. Speciation studies were performed to explore the solution stability of curcumin complexes formed with [Rh(η-CMe)(HO)]. Acetylacetone (Hacac), as the simplest β-diketone ligand bearing (O,O) donor set, was involved for comparison and its Ru(η‑p‑cymene), Ru(η‑toluene) complexes were also studied. H NMR, UV-visible and pH-potentiometric titrations revealed a clear trend of stability constants of the acac complexes: Ru(η‑p‑cymene) > Ru(η‑toluene) > Rh(η-CMe). Despite this order, the highest extent of complex formation is seen for the Rh(η-CMe) complexes at pH 7.4. Formation constant of [Rh(η-CMe)(Hcurcumin)(HO)] reveals similar solution stability to that of the acac complex. Additionally, structures of two complexes were determined by X-ray crystallography. The in vitro cytotoxicity of curcumin was not improved by the complexation with these organometallic cations.


Journal Details

This article was published in the following journal.

Name: Journal of inorganic biochemistry
ISSN: 1873-3344
Pages: 91-100


DeepDyve research library

PubMed Articles [20827 Associated PubMed Articles listed on BioPortfolio]

Serendipitous Synthesis of Five-Coordinated Half-Sandwich Aminoimine Iridium(III) and Ruthenium(II) Complexes and Their Application as Potent Anticancer Agents.

Stable five-coordinated (16-electron) half-sandwich iridium(III) and ruthenium(II) complexes are rarely reported, and their biological evaluations have not been considered to date. Herein, in an exper...

Structure-activity relationship studies of antiplasmodial cyclometallated ruthenium(II), rhodium(III) and iridium(III) complexes of 2-phenylbenzimidazoles.

Benzimidazoles, such as albendazole, thiabendazole and omeprazole have antiplasmodial activity against Plasmodium falciparum and are widely used as scaffolds for metal-based drug research. Incorporati...

Rhodium-Catalyzed Synthesis of Silicon-Bridged 1,2-Dialkenylbenzenes via 1,4-Rhodium Migration.

An efficient synthesis of 1,3-dialkylidene-2,3-dihydro-1 H-benzo[ c]siloles, a new type of silicon-bridged π-conjugated compounds, was developed from a simple substrate combination of dialkynylsilane...

Fluxional bonds in quasi-planar and half-sandwich (M = K, Rb, and Cs).

Detailed molecular orbital and bonding analyses reveal the existence of both fluxional σ- and π-bonds in the global minima C (1) and C MB (3) and transition states C (2) and C (4) of dianion and m...

Novel Half-sandwich Iridium OˆC (carbene)-Complexes: In Vitro and In Vivo Tumor Growth Suppression and pro-apoptosis Via ROS-mediated Cross-talk Between Mitochondria and Lysosomes.

Herein we present half-sandwich Ir complexes [(η-Cp)Ir(OˆC)Cl] containing OˆC(NHC)-chelating ligand as anticancer and antimetastasis agents. All the complexes displayed high potency in vitro agains...

Clinical Trials [5750 Associated Clinical Trials listed on BioPortfolio]

A Cognitive Behavioral And Structural HIV Prevention Intervention for Young Ugandan Sex Workers

This study develops and tests a behavioural and structural intervention to prevent unprotected sex among young female sex workers. Half the participants will receive the intervention and h...

High Strong Ion Difference Fluid vs Hartmann's Solution on Acid-Base Status in Sepsis

This is a research to study primarily the effect of rapidly infused high strong ion difference (SID) fluid vs Hartmann's solution in altering the pH and bicarbonate level of the patient, w...

"Sandwich" Chemotherapy With Radiotherapy in Newly Diagnosed, Stage IE to IIE, ENKTL

A phase 2 study was conducted of "sandwich" protocols, with earlier RT after an initial 2 of P-CHOP (Pegaspargase, cyclophosphamide,vincristine, doxorubicin and dexamethasone ), followed b...

The Caries-arresting Effect of Incorporating fTCP to NaF Varnish Applied Following AgNO3 in Preschool Children

The objective of this study is to compare the effectiveness of 25% AgNO3 solution plus 5% NaF varnish and 25% AgNO3 solution plus 5% NaF varnish with fTCP when applied semi-annually over 3...

Study of INS365 Ophthalmic Solution in a Controlled Adverse Environment in Patients With Dry Eye

Comparative efficacy trial of INS365 Ophthalmic Solution and placebo in patients with dry eye.

Medical and Biotech [MESH] Definitions

Unstable isotopes of ruthenium that decay or disintegrate emitting radiation. Ru atoms with atomic weights 93-95, 97, 103, and 105-108 are radioactive ruthenium isotopes.

Rhodium. A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh. (Dorland, 28th ed)

Inorganic compounds that contain ruthenium as an integral part of the molecule.

Comparative studies to verify the effectiveness of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques determined in phase II studies. During these trials, patients are monitored closely by physicians to identify any adverse reactions from long-term use. These studies are performed on groups of patients large enough to identify clinically significant responses and usually last about three years. This concept includes phase III studies conducted in both the U.S. and in other countries.

Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)

Quick Search


DeepDyve research library

Relevant Topic

Radiology is the branch of medicine that studies imaging of the body; X-ray (basic, angiography, barium swallows), ultrasound, MRI, CT and PET. These imaging techniques can be used to diagnose, but also to treat a range of conditions, by allowing visuali...

Searches Linking to this Article