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Supraphysiologic parenteral ascorbic acid blunts the inflammatory mediator response to pathogen associated molecular patterns in dogs ex vivo.

08:00 EDT 12th March 2019 | BioPortfolio

Summary of "Supraphysiologic parenteral ascorbic acid blunts the inflammatory mediator response to pathogen associated molecular patterns in dogs ex vivo."

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This article was published in the following journal.

Name: Research in veterinary science
ISSN: 1532-2661
Pages: 228-232

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PubMed Articles [19348 Associated PubMed Articles listed on BioPortfolio]

Unraveling the mechanism of l-gulonate-3-dehydrogenase inhibition by ascorbic acid: Insights from molecular modeling.

l-Gulonate dehydrogenase (GuDH) is a crucial enzyme in the non-phosphorylated sugar metabolism or glucuronate-xylulose (GX) pathway. Some naturally occurring compounds inhibit GuDH. Ascorbic acid is o...

Childhood Adversity Impact on Gut Microbiota and Inflammatory Response to Stress During Pregnancy.

Adverse childhood experiences (ACEs), such as abuse or chronic stress, program an exaggerated adult inflammatory response to stress. Emerging rodent research suggests that the gut microbiome may be a ...

Electrochemical sensor based on a nanocomposite prepared from TmPO and graphene oxide for simultaneous voltammetric detection of ascorbic acid, dopamine and uric acid.

A nanocomposite is described that consists of TmPO and graphene oxide (GO) and is used to modify a glassy carbon electrode (GCE) to obtain a sensor for simultaneous determination of ascorbic acid (AA)...

Switchable fluorescence of MoS quantum dots: a multifunctional probe for sensing of chromium(VI), ascorbic acid, and alkaline phosphatase activity.

A simple strategy for modulating the fluorescence of MoS quantum dots (QDs) is described. The fluorescence of MoS QDs was firstly switched off by the addition of Cr(VI), and the quenched fluorescence ...

Ascorbic acid and thiols as potential biomarkers of ozone tolerance in tropical wheat cultivars.

Tropospheric ozone (O) has been identified as the most damaging air pollutant to crop plants in terms of growth and yield reductions. Considering the negative effect of O in tropical regions, fourteen...

Clinical Trials [8842 Associated Clinical Trials listed on BioPortfolio]

A Trial to Assess the Impact of Ascorbic Acid on Cardiac Surgeries Outcomes and Complications''

this study is evaluating the safety and efficacy of ascorbic acid as a drug that can decrease inflammatory complications post surgical in addition to its impact on decreasing risk of arrhy...

Impact of Ascorbic Acid in the Prevention of Vancomycin Induced Nephrotoxicty

A Randomized controlled trial aiming to investigate whether ascorbic acid has a role in preventing vancomycin induced nephrotoxicity or not in critically ill patients.

Ascorbic Acid Treatment in Congenital Glucocorticoids and Mineralocorticoids Deficiency Due to NNT Mutation

Nicotinamide nucleotide transhydrogenase (NNT) mutations cause glucocorticoid and mineralocorticoid deficiencies through decreased detoxification of reactive oxygen species (ROS) in adreno...

Ascorbic Acid Treatment in CMT1A Trial (AATIC)

Charcot-Marie-Tooth type IA (CMT1A) is the most prevalent hereditary peripheral neuropathy. Demyelination of peripheral nerves is the hallmark of CMT1A. Ascorbic acid has been shown to hav...

Ascorbic Acid on Restenosis of Dysfunctional Hemodialysis Vascular Access

To investigate the effect of ascorbic acid on angiographic restenosis after percutaneous transluminal angioplasty (PTA) for dysfunctional dialysis vascular access.

Medical and Biotech [MESH] Definitions

A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into SCURVY in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)

A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.

A mediator complex subunit that is believed to play a key role in the coactivation of nuclear receptor-activated transcription by the mediator complex. It interacts with a variety of nuclear receptors including RETINOIC ACID RECEPTORS; THYROID HORMONE RECEPTORS; VITAMIN D RECEPTORS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; ESTROGEN RECEPTORS; and GLUCOCORTICOID RECEPTORS.

Metabolite of ASCORBIC ACID and the oxidized form of the lactone DEHYDROASCORBIC ACID.

The reversibly oxidized form of ascorbic acid. It is the lactone of 2,3-DIKETOGULONIC ACID and has antiscorbutic activity in man on oral ingestion.

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