A survival guide to HER 2 testing in gastric/gastroesophageal junction carcinoma.

08:00 EDT 27th March 2019 | BioPortfolio

Summary of "A survival guide to HER 2 testing in gastric/gastroesophageal junction carcinoma."

HER2 status determines gastric/gastroesophageal (GEJ) adenocarcinomas that benefit from targeted therapy; hence, HER2 testing has become a routine practice. Accurate HER2 testing is fundamental to select eligible patients who will benefit from HER2 targeted treatment. Reported HER2 positive rate in gastric/GEJ cancers ranges from 4.4% to 53.4% and HER2-positive tumors are considered to have more aggressive biological behavior and tumor recurrence. Main modalities of HER2 testing in clinical practice include immunohistochemistry (IHC) for protein expression and in-situ hybridization (ISH) for gene amplification. There are many technical pitfalls which affect the accuracy of HER2 result. Additionally, there are several issues in HER2 testing related to the tumor biology, sample selection, interpretation of IHC and ISH results, and finally confirming the HER2 status. Therefore, gastric/GEJ adenocarcinoma specific HER2 testing protocols have been developed and standardized to minimize the impact of these pre-analytical and analytical factors, and to enhance reproducibility of HER 2 testing results. This review provides up to date practical guidance to clinicians on accurate HER2 testing and interpretation of results in gastric/gastro esophageal junction adenocarcinoma.


Journal Details

This article was published in the following journal.

Name: Gastrointestinal endoscopy
ISSN: 1097-6779


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Medical and Biotech [MESH] Definitions

Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.

That portion of the stomach remaining after gastric surgery, usually gastrectomy or gastroenterostomy for cancer of the stomach or peptic ulcer. It is a common site of cancer referred to as stump cancer or carcinoma of the gastric stump.

GASTROESOPHAGEAL REFLUX wherein the retrograde flow passes through the UPPER ESOPHAGEAL SPHINCTER

The physiologic or functional barrier to GASTROESOPHAGEAL REFLUX at the esophagogastric junction. Sphincteric muscles remain tonically contracted during the resting state and form the high-pressure zone separating the lumen of the ESOPHAGUS from that of the STOMACH. (Haubrich et al, Bockus Gastroenterology, 5th ed., pp399, 415)

Back flow of gastric contents to the LARYNGOPHARYNX where it comes in contact with tissues of the upper aerodigestive tract. Laryngopharyngeal reflux is an extraesophageal manifestation of GASTROESOPHAGEAL REFLUX.

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