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O-Methyl Phytocannabinoids: Semi-synthesis, Analysis in Cannabis Flowerheads, and Biological Activity.

08:00 EDT 1st April 2019 | BioPortfolio

Summary of "O-Methyl Phytocannabinoids: Semi-synthesis, Analysis in Cannabis Flowerheads, and Biological Activity."

A general protocol for the selective mono-methylation of resorcinyl phytocannabinoids was developed. The availability of semisynthetic monomethyl analogues of cannabigerol, cannabidiol, and cannabidivarin (1
A:
-3
A:
, respectively) made it possible to quantify these minor phytocannabinoids in about 40 different chemotypes of fiber hemp. No chemotype significantly accumulated mono--methyl cannabidiol (2
B:
) or its lower homologue (3
B:
), while at least three chemotypes containing consistent amounts (≥ 400 mg/kg) of -methylcannabigerol (1
B:
) were identified. -Methylation of alkyl phytocannabinoids (1
B:
-3
B:
) does not significantly change the activity on peroxisome proliferator-activated receptors in contrast to what was reported for phenethyl analogues.

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This article was published in the following journal.

Name: Planta medica
ISSN: 1439-0221
Pages:

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