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With their gradual and continuous properties, functionally graded polymers (FGP) have high potentials to reproduce the regional variation in microstructure/property of the natural intervertebral disc and, therefore, the functional anatomy and biomechanics of the soft tissue. This paper evaluates by finite element analysis the biomechanical response and stress distribution of a novel disc prosthesis using FGP. The kinetics of the FGP parameters is designed using experimental data issued from linear ethylene copolymers over a wide crystallinity range. The radial variation in crystallinity index within the disc prosthesis varies gradually and continuously following a special function in the aim to tailor and optimize the FGP parameters. The experimental data of a healthy human cervical spine segment are used to predict the optimal model of the FGP disc prosthesis loaded under different physiological loading conditions, i.e. rotation, lateral bending and flexion/extension. The results suggest that the FGP parameters can be tailored to control the stiffening, the non-linear behavior, the inelastic effects and the stress distribution in the aim to propose the optimal prosthesis model giving the great opportunity of patient-specific FGP prostheses via 3D printing technologies.
This article was published in the following journal.
Name: Journal of the mechanical behavior of biomedical materials
Intervertebral disc degeneration was characterized with aberrant intervertebral disc nucleus pulposus cells apoptosis. MiR-532 was reported to be up-regulated in the patients with intervertebral disc ...
A rat puncture injury intervertebral disc (IVD) degeneration model with structural, biomechanical, and histological analyses.
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Comparison of Software-assisted Implantation of Elastic Spine Pad (TM) With Respect to Postoperative Change in Neck Disability Index (NDI) With the Conventional Disc Prosthesis Rotaio (TM) After Anterior Cervical Discectomy for Cervical Disc Prolapse
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Comparison of Software-assisted Implantation of Elastic Spine Pad (TM) With Respect to Postoperative Change in Neck Disability Index (NDI) With the Conventional Disc Spacer Squale (TM) After Anterior Cervical Discectomy for Cervical Disc Prolapse
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The dissolving of the NUCLEUS PULPOSUS, the semi-gelatinous tissue of a displaced INTERVERTEBRAL DISC. It is usually achieved by the direct injection of a proteolytic enzyme, especially CHYMOPAPAIN, into the herniated disc.
Fibrocartilage inner core of the intervertebral disc. Prolapsed or bulged nucleus pulposus leads to INTERVERTEBRAL DISC DISPLACEMENT while proliferation of cells in the nucleus pulposus is associated with INTERVERTEBRAL DISC DEGENERATION.
Degenerative changes in the INTERVERTEBRAL DISC due to aging or structural damage, especially to the vertebral end-plates.
An INTERVERTEBRAL DISC in which the NUCLEUS PULPOSUS has protruded through surrounding ANNULUS FIBROSUS. This occurs most frequently in the lower lumbar region.
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