Close to the Bedside: A Systematic Review of Endogenous Retroviruses and Their Impact in Oncology.

08:00 EDT 29th March 2019 | BioPortfolio

Summary of "Close to the Bedside: A Systematic Review of Endogenous Retroviruses and Their Impact in Oncology."

Human endogenous retroviruses (HERVs) are genetic elements in the human genome, which resulted from ancient retroviral germline infections. HERVs have strong transcriptional promoters and enhancers that affect a cell's transcriptome. They also encode proteins that can exert effects in human cells. This review examines how our increased understanding of HERVs have led to their potential use as biomarkers and immunologic targets.


Journal Details

This article was published in the following journal.

Name: The Journal of surgical research
ISSN: 1095-8673
Pages: 145-155


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Medical and Biotech [MESH] Definitions

Retroviruses that have integrated into the germline (PROVIRUSES) that have lost infectious capability but retained the capability to transpose.

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