Rapid synthesis of N-glycan oxazolines from locust bean gum via the Lafont rearrangement.

08:00 EDT 23rd March 2019 | BioPortfolio

Summary of "Rapid synthesis of N-glycan oxazolines from locust bean gum via the Lafont rearrangement."

Enzymatic degradation of locust bean gum provides a Manβ(1 → 4)Man disaccharide, which may be converted into the core Manβ(1 → 4)GlcNAc disaccharide unit of all N-glycans via conversion to a 2-iodo-glycosyl azide, and Lafont rearrangement. The Manβ(1 → 4)GlcNAc disaccharide may be used as a key intermediate for elaboration into more complex N-glycan structures providing a route to N-glycan oxazolines as donor substrates for ENGase enzymes that is considerably shorter than those reported previously.


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This article was published in the following journal.

Name: Carbohydrate research
ISSN: 1873-426X
Pages: 11-19


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