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Quercetin-Modified Metal-Organic Frameworks for Dual Sensitization of Radiotherapy in Tumor Tissues by Inhibiting the Carbonic Anhydrase IX.

08:00 EDT 1st April 2019 | BioPortfolio

Summary of "Quercetin-Modified Metal-Organic Frameworks for Dual Sensitization of Radiotherapy in Tumor Tissues by Inhibiting the Carbonic Anhydrase IX."

The development of multifunctional nanoscale radiosensitizers have been attracted tremendous amount of attention, which can enhance radiosensitization of tumor tissues and reduce unnecessary damage to the surrounding organs. However, the persistent hypoxia environment within the tumor limits their applications in radiotherapy. In this paper, a stable nanocomposite was engineered to overcome the hypoxia properties by using 1,4-benzenedicarboxylic acid produced from Zr-MOF as Carbonic Anhydrase IX (CA IX) inhibitor and quercetin (QU) as a radiosensitizer. QU was encapsulated into Zr-MOF structure to achieve the synergetic dual sensitization therapy. Zr-MOF-QU exhibits excellent potential of radiotherapy sensitization characteristics in vitro and in vivo from the γ-H2AX immunofluorescence staining and colony assays. The mechanisms of alleviating hypoxia-induced resistance and sensitizing tumor tissues to improve cell apoptosis of radiation were found to suppress CA IX expressions by the decomposition product form Zr-MOF and boost the sensitivity by QU in RT. Moreover, there was no significant systemic toxicity during the treatment, and the therapeutic outcome was assessed in animal models. Therefore, our results demonstrated a promising cancer treatment approach in radiation field.

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This article was published in the following journal.

Name: ACS nano
ISSN: 1936-086X
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