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Triplet dynamic nuclear polarization (triplet-DNP), a method to enhance the NMR and MRI sensitivity using photo-excited triplet electrons, has a great potential to hyperpolarize nuclear spins at room temperature. Since the first report of room-temperature triplet-DNP in 1990, pentacene has been the only and best option of triplet polarizing agents. However, the poor air-stability of pentacene has severely limited the applicability of triplet-DNP. Here, we report the first example of polarizing agents with significant air-stability as well as high polarizing ability comparable to pentacene. The introduction of electron-withdrawing diaza-substitution to pentacene and tetracene reduces the LUMO level and endows much-improved stability under the ambient condition. Importantly, the diaza-substituted pentacene and tetracene offer similar, or even slightly better, 1H NMR signal enhancement compared with pentacene in the prototypical triplet-DNP test using p-terphenyl crystals. This work removes one of the largest obstacles towards the application of triplet-DNP for hyperpolarization of biological molecules.
This article was published in the following journal.
Name: The journal of physical chemistry letters
While dynamic nuclear polarization based on photoexcited triplet electrons (triplet-DNP) has the potential to hyperpolarize nuclear spins of target substrates in the low magnetic field at room tempera...
Unlike previously well-studied, acyclic pentacene oligomers, here we report the first synthesis of a cyclic pentacene trimer with a fixed tubular conformation. A short-step synthesis starting from com...
Supramolecular assembly of urea-tethered benzophenone molecules results in the formation of remarkably persistent triplet radical pairs upon UV-irradiation at room temperature, whereas no radicals wer...
In condensed solid, triplet exciton migration and succeeding triplet-triplet annihilation (TTA) are major bottleneck processes for efficient photon upconversion (UC) using sunlight excitation. We theo...
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Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302)
The condition of carrying TRIPLETS simultaneously.
Sequences within RNA that regulate the processing, stability (RNA STABILITY) or translation (TRANSLATION, GENETIC) of RNA.
A technique of diagnostic imaging of RETINA or CORNEA of the human eye involving the measurement and interpretation of polarizing ELECTROMAGNETIC WAVES such as radio or light waves. It is helpful in the diagnosis of GLAUCOMA; MACULAR DEGENERATION; and other retinal disorders.
The use of chemical agents in TERRORISM. This includes the malevolent use of nerve agents, blood agents, blister agents, and choking agents (NOXAE).
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