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Differentiation and replication are the two major fates of the cells. They are the fundamental processes for completing the cellular functions. Although the underlying biological processes have been considerably explored for each of these processes and significant progresses have been made, global quantification and physical understanding are still challenging especially for the relationship among them. In this study, we developed a theoretical framework for both the cell cycle and cell differentiation by exploring the associated global dynamics and their underlying relationship. We found that the dynamics of the cell cycle and cell differentiation is governed by both the landscape gradient and rotational curl flux. While landscape attracts the system down to the stable state basins, the curl flux drives the stable oscillation flow. We uncovered the irregular Mexican hat landscapes of the cell cycle at different developmental stages. We studied how the cells develop from undifferentiated cells to differentiated cells and how the cell cycle proceeds at different developmental stages. We investigated how the cell differentiation can influence the cell cycle where more progressive differentiation can lead to the changes of the cell cycle oscillations. In contrast, we can also quantitatively illustrate how the cell cycle can influence the cell differentiation where cell cycle regulation can lead to the changes of the differentiation processes. Through the landscape and flux analysis, we uncovered the key regulatory elements controlling the progression of the cell differentiation and cell cycle. This can help to design an effective strategy for drug discovery against associated diseases.
This article was published in the following journal.
Name: The journal of physical chemistry. B
Models describing the process of stem-cell differentiation are plentiful, and may offer insights into the underlying mechanisms and experimentally observed behaviour. Waddington's epigenetic landscape...
Cytokinesis is the subject of intense study, but mechanisms underlying contractility and cell shape change in cytokinesis are still being defined. Furthermore, it is unknown how contractile mechanisms...
DNA methylation is an important epigenetic mark that plays a vital role in gene expression and cell differentiation. The average DNA methylation level among a group of cells has been extensively docum...
Cardiac differentiation of human pluripotent stem cells (hPSCs) requires orchestration of dynamic gene regulatory networks during stepwise fate transitions but often generates immature cell types that...
It is an incredible honor to receive the Woman in Cell Biology Mid-Career Award for Excellence in Research. My lab works on cell-cell fusion, an indispensable process in the conception, development, a...
Animal data showing decreased myocardial inflammation, damage, and mortality, and improved cardiac function with CD40L/B7-1 and CTLA4 blockage, coupled with our preliminary findings of low...
This is a multi-centric, open-label study evaluating the efficacy and safety of RAD001 in patients with advanced (stage IV) Lung Cancer (Large Cell) with neuroendocrine differentiation tre...
The purpose of this research is to better characterize the components and mechanisms of the immune systems of persons with sickle cell disease who have had a kidney transplant and are immu...
Cluster of differentiation antigen 19(CD19) specifically presents in B lymphocyte cell lines steadily,while not in most normal tissue,including pluripotent hematopoietic stem cells.Cluster...
Stem cells can develop into every cell, every tissue and every organ in the human body, e.g., they can make any kind of cells in the human body. Stem cells reproduce themselves many times...
The mechanisms by which a cell becomes internalized in another. The host cell may engulf another as do PHAGOCYTIC CELLS, or the host cell may be invaded by another cell (ENTOSIS), or internalization processes may involve the cooperation of both the host cell and the cell being internalized. Viable cells may remain in non-phagocytic cells (EMPERIPOLESIS), undergo cell division, pass through and then out of the host cell (TRANSCELLULAR CELL MIGRATION), or trigger APOPTOSIS of the invaded cell.
Inhibitor of differentiation proteins are negative regulators of BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS. They inhibit CELL DIFFERENTIATION and induce CELL PROLIFERATION by modulating different CELL CYCLE regulators.
Direct contact of a cell with a neighboring cell. Most such junctions are too small to be resolved by light microscopy, but they can be visualized by conventional or freeze-fracture electron microscopy, both of which show that the interacting CELL MEMBRANE and often the underlying CYTOPLASM and the intervening EXTRACELLULAR SPACE are highly specialized in these regions. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p792)
Antigens expressed on the cell membrane of T-lymphocytes during differentiation, activation, and normal and neoplastic transformation. Their phenotypic characterization is important in differential diagnosis and studies of thymic ontogeny and T-cell function.
A family of GLYCOSYLPHOSPHATIDYLINOSITOL-anchored, cell-surface heparan sulfate proteoglycans that may play a role in CELL GROWTH PROCESSES and CELL DIFFERENTIATION by modulating ligand-receptor interactions.
Biological therapy involves the use of living organisms, substances derived from living organisms, or laboratory-produced versions of such substances to treat disease. Some biological therapies for cancer use vaccines or bacteria to stimulate the body&rs...