Photo-Controllable Proteins for Optoacoustic Imaging.

08:00 EDT 1st April 2019 | BioPortfolio

Summary of "Photo-Controllable Proteins for Optoacoustic Imaging."

Photo-controllable proteins revolutionized life-science imaging due to their contribution to subdiffraction-resolution optical microscopy. They might have yet another lasting impact on Photo- or Optoacoustic imaging (OA). OA combines optical contrast with ultrasound detection enabling high-resolution real-time in vivo imaging well-beyond the typical penetration depth of optical methods. While OA already showed numerous applications relying on endogenous contrast from blood hemoglobin or lipids its application in the life-science was limited by a lack of labels overcoming the strong signal from the aforementioned endogenous absorbers. Here, a number of recent studies showed that photo-controllable proteins provide the means to overcome this barrier eventually enabling OA to image small cell numbers in a complete organism in vivo. In this Feature article, we introduce the key photo-controllable proteins, explain the basic concepts and highlight achievements that have been already made.


Journal Details

This article was published in the following journal.

Name: Analytical chemistry
ISSN: 1520-6882


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