Sesquiterpenoid compounds from Curcuma kwangsiensis (Thunb.) Sweet.

08:00 EDT 1st April 2019 | BioPortfolio

Summary of "Sesquiterpenoid compounds from Curcuma kwangsiensis (Thunb.) Sweet."

Two previously undescribed guaiane-type sesquiterpenes (1-2), a pair of new salvialane-type sesquiterpenes (3a and 3b), together with 11 known compounds were isolated and purified from the rhizomes of Curcuma kwangsiensis. Their structures were elucidated by the extensive spectroscopic data (1D and 2D NMR) analysis. All the isolated compounds were assessed for their anti-neuroinflammatory activity by inhibiting the nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine BV-2 microglial cells in vitro assay, and the isolates 3 and 11 showed anti-neuroinflammatory activity with IC50 values 1.85 and 20.05 μM, respectively.


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This article was published in the following journal.

Name: Chemistry & biodiversity
ISSN: 1612-1880


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